Cyclodextrin nanosponges as effective gas carriers

Trotta, Francesco; Cavalli, Roberta; Martina, Katia; Biasizzo, Miriam; Vitillo, Jenny G.; Bordiga, Silvia; Vavia, Pradeep R.; Ansari, Khalid

doi:10.1007/s10847-011-9926-5

Cited by 84 publications

(70 citation statements)

References 14 publications

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“…[38] In Food Industry: Nanosponges are useful for masking, reduction and elimination of bitter components from fruit juices and other dietary products by selective combination of polymer and crosslinker. [39] Chemotherapy: Nanosponges have been studied as a potential delivery system for anticancer therapies in which enhancement of bioavailability and activity was seen in molecules such as Paclitaxel and Tamoxifen. Different cancer cells had been treated by nanosponges like breast cancer or fast acting glioma type with help of single dose of injections.…”

Section: Applicationsmentioning

confidence: 99%

Microsponges: Topical Preparation and Its Applications

Sumbria¹

2017

WJPPS

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Microsponges are polymeric delivery systems composed of porous microspheres. They are tiny sponge-like spherical particles with a large porous surface. Moreover, they may enhance stability, reduce side effects and modify drug release favorably. Microsponge technology has many favorable characteristics, which make it a versatile drug delivery vehicle. Microsponge Systems are based on microscopic, polymer-based microspheres that can suspend or entrap a wide variety of substances, and can then be incorporated into a formulated product such as a gel, cream, liquid or powder. The outer surface is typically porous, allowing a sustained flow of substances out of the sphere.Microsponges are porous, polymeric microspheres that are used mostly for topical use and have recently been used for oral administration. More and more developments in delivery systems are being integrated to optimize the efficacy and cost-effectiveness of the therapy.Microsponge technology offers entrapment of ingredients and is believed to contribute towards reduced side effects, improved stability, increased elegance, and enhanced formulation flexibility. In addition, numerous studies have confirmed that microsponge systems are non-irritating, nonmutagenic, non-allergenic, and non-toxic. Microsponges are being used currently in cosmetics, over-the-counter (OTC) skin care, sunscreens and prescription products. One of the best feature of microsponge is it is self-sterilizing. This review is based on method of preparation and applications of microsponges.

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Section: Applicationsmentioning

confidence: 99%

Microsponges: Topical Preparation and Its Applications

Sumbria¹

2017

WJPPS

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“…In another recent cyclodextrin-mediated encapsulation study, their abilities to trap and store gases, including CO 2 , were investigated (Trotta et al, 2011). Molecular encapsulation of gases in cyclodextrins is best done using α-cyclodextrin due to its tight inner cavity, although cyclodextrin "nanosponges" formed by cross linking β-cyclodextrins can also effectively complex with gases (Cavalli, Trotta, & Tumiatti, 2006).…”

Section: Cyclodextrinsmentioning

confidence: 99%

“…Molecular encapsulation of gases in cyclodextrins is best done using α-cyclodextrin due to its tight inner cavity, although cyclodextrin "nanosponges" formed by cross linking β-cyclodextrins can also effectively complex with gases (Cavalli, Trotta, & Tumiatti, 2006). Crystalline complexes were found to be stable for months at room temperature and gas was released by subsequent dissolution of the crystalline complex in water (Trotta et al, 2011). CO 2 was entrapped in β-cyclodextrin carbonate nanosponges at atmospheric pressure and room temperature, and the entrapment was even strong at 100ºC for 36 h under vacuum (Trotta et al, 2011).…”

Section: Cyclodextrinsmentioning

confidence: 99%

“…Crystalline complexes were found to be stable for months at room temperature and gas was released by subsequent dissolution of the crystalline complex in water (Trotta et al, 2011). CO 2 was entrapped in β-cyclodextrin carbonate nanosponges at atmospheric pressure and room temperature, and the entrapment was even strong at 100ºC for 36 h under vacuum (Trotta et al, 2011). Thus, nanosponges may be useful in food applications such as confections or carbonated frozen food product development.…”

Section: Cyclodextrinsmentioning

confidence: 99%

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Nanotechnology: the word is new but the concept is old. An overview of the science and technology in food and food products at the nanoscale level

Bryksa

Yada

2012

Int. J. Food Stud.

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Food scientists and technologists are actively engaged in examining and developing nanotechnologies for applications such as novel functional ingredients and nutrient delivery systems, safety testing, packaging, and authenticity/authentication at an ever-increasing pace. However, before these new products/technologies are commercialised, rigorous safety testing and risk/benefit analysis are required to ensure that public and environmental concerns are addressed. This review provides an overview of food nanoscience and technology including a brief history, education, definitions pertaining to policy and regulation, and applications. The most recent findings and advances are emphasised, focussing on bioactives' delivery. In addition, proposed directions in the area of nano-based targeting of pathogens for food safety as well as medical foods are discussed. As food nanoscience and technology has been extenisvely reviewed in recent years, specific case examples will be limited to those reported within the past year.

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“…Thus, effective formulation design can be a useful approach which results in improved solubility, absorption and in total oral bioavailability of such drug candidates (Pouton et al, 2006). There are the several formulation approaches to increase the solubility of poorly water soluble drugs like cyclodextrin, nanosponges and nanoparticles (Khalid et al, 2011;Khalid et al, 2011;Satyen et al 2010;Francesco et al, 2011;Ridhurkar et al, 2012;Nekkanti et al, 2011). However, Self-microemulsifying drug delivery systems (SMEDDS) are among the methods used to improve the oral bioavailability of poorly soluble drugs (Hong et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Design and optimization of self-microemulsifying drug delivery system (SMEDDS) of felodipine for chronotherapeutic application

Storti-Filho

Damke

Carrara

et al. 2014

Braz. J. Pharm. Sci.

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The objective of this research work was to design, develop and optimize the self micro-emulsifying drug delivery system (SMEDDS) of Felodipine (FL) filled in hard gelatine capsule coated with polymer in order to achieve rapid drug release after a desired time lag in the management of hypertension. Microemulsion is composed of a FL, Lauroglycol FCC, Transcutol P and Cremophor EL. The optimum surfactant to co-surfactant ratio was found to be 2:1. The resultant microemulsions have a particle size in the range of 65-85 nm and zeta potential value of -13.71 mV. FL release was adequately adjusted by using pH independent polymer i.e. ethyl cellulose along with dibutyl phthalate as plasticizer. Influence of formulation variables like viscosity of polymer, type of plasticizer and percent coating weight gain was investigated to characterize the time lag. The developed formulation of FL SMEDDS capsules coated with ethyl cellulose showed time lag of 5-7 h which is desirable for chronotherapeutic application.Uniterms: Felodipine/self-microemulsifying delivery. Felodipine/chronotherapeutic application. Selfmicroemulsifying drug delivery system/development. Drugs/controlled release. Ethyl cellulose/drugs coated. Hypertension/treatment. Chronotherapeutics/hypertension treatment.O objetivo desse trabalho de pesquisa foi planejar, desenvolver e otimizar sistema de liberação de fármaco auto-microemulsificante(SMEDDS) de felodipino (FL) em cápsulas de gelatina dura revestidas com polímero, a fim de obter liberação rápida após tempo desejado no manejo da hipertensão. A microemulsão é composta de FL, lauroglilcol FCC, Transcutol P e Cremophor EL. A proporção ótima de tensoativo e de co-tensoativo foi de 2:1. As microemulsões resultantes têm tamanho de partícula na faixa de 65-85 nm com potencial zeta de -13,71 mV. A liberação de FL foi ajustada adequadamente, utilizando-se polímero independente de pH, como etilcelulose com ftalato de dibutila como plastificante. A influência das variáveis da formulação, como viscosidade do polímero, tipo de plastificante e ganho percentual de peso do revestimento foi investigada para caracterizar o intervalo de tempo de liberação. A formulação de cápsulas de FL SMEDDS revestidas com etilcelulose mostrou intervalo de tempo de liberação de 5 a 7 horas, o que é desejável para uma aplicação cronoterapêutica.Uniterms: Felodipino/liberação de fármaco auto-emulsificante. Felodipino/aplicação cronoterapêutica. Sistema de liberação de fármaco auto-emulsificante/desenvolvimento. Fármacos/liberação controlada. Etilcelulose/revestimento de fármacos. Hipertensão/tratamento. Cronoterapia/tratamento da hipertensão.

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Cyclodextrin nanosponges as effective gas carriers

Cited by 84 publications

References 14 publications

Microsponges: Topical Preparation and Its Applications

Microsponges: Topical Preparation and Its Applications

Nanotechnology: the word is new but the concept is old. An overview of the science and technology in food and food products at the nanoscale level

Design and optimization of self-microemulsifying drug delivery system (SMEDDS) of felodipine for chronotherapeutic application

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