stay of 5.7 days. Sixty (17.4%) patients had severe disease, defined as admission to intensive care unit (5.5%, n = 19), requiring mechanical ventilation (13.9%, n = 48) or death (4.9%, n = 17). At least one respiratory virus was identified in 195 (56.5%) patients, of which 24 (7%) were co-infections. The most detected viruses were rhinovirus/enterovirus (51%, n = 176), influenza virus (7.5%, comprising 13 A/H3N2, 8 A/H1N1 and 5 influenza B), parainfluenza virus (2.3%, n = 8), respiratory syncytial virus (0.9%, n = 3), metapneumovirus (0.9%, n = 3), coronavirus OC43 (0.6%, n = 2) and adenovirus (0.3%, n = 1). Of 150 (43.5%) negative samples, 48 samples were selected for viral metagenomics analysis. At least one respiratory virus was detected in 14 (29.2%) NGS samples: rhinoviruses (18.8%, n = 9), influenza virus (8.3%, with 3 A/H3N2 and 1 influenza B), and enteroviruses (4.2%, n = 2). No avian influenza virus, MERS-CoV and SARS-CoV was detected in this study. Only 28 (8.1%) patients had significant positive blood cultures, most commonly Klebsiella pneumoniae, Streptococcus pneumoniae and Staphylococcus aureus. Severe disease was independently associated with significant positive blood culture (OR 2.78, 95% CI 1.18-6.59, p = 0.02), but not with any viruses.Conclusion: Rhinovirus/enterovirus and influenza virus are the most frequently detected viruses in adults with SARI, although the clinical significance of the former is not certain. NGS showed that known respiratory viruses play an important etiologic role in unexplained SARIs cases and no emerging respiratory viruses were detected in this study.
BACKGROUND In response to the COVID-19 pandemic, the parent study halted recruitment of pediatric traumatic brain injury (TBI) participants into a biobank because in-person enrollment was critical for proper consent and biospecimen procurement. Despite this, the research team maintained existing digital screening efforts to identify potential participants. OBJECTIVE The primary objective of this exploratory, retrospective study is to evaluate pediatric TBI emergency department (ED) utilization during the pandemic. The secondary objective aims to appraise the efficacy of the research team’s internal screening processes. METHODS Candidates (i.e. a person who presented to the ED with census data suggesting a potential TBI) were screened from an ED’s Electronic Health Record (EHR) system. A potential participant is defined as an individual who met all inclusion criteria and would be approached by a consenter after further chart review. Preliminary data was cleaned through Google Sheets, which were then coded as ten variables to examine the effects of the pandemic on internal operations and hospital utilization patterns. These variables were compared between select months during the pandemic in 2020 to analogous months in 2019 in the programming language R. RESULTS The sample (N=2321) consisted of 1245 entries from 2019 and 1076 entries from 2020. A significantly greater proportion of potential participants were identified in 2020 (222/633; 35.1%) versus 2019 (195/908; 21.4%). A significantly greater proportion of potential participants had a visit reason indicative of a TBI in 2020 (181/222; 81.5%) versus 2019 (103/195; 52.8%). A significantly greater proportion of these injuries occurred inside (39/181; 21.5%) in 2020 versus 2019 (11/103; 10.7%). No significant difference was found across the mechanism of injury categories reported for potential participants between 2019 and 2020. Potential participants were significantly older in 2019 (mean=8.93) versus 2020 (mean=7.31). Screeners spent significantly longer to identify potential participants in March 2020 (55 minutes) versus March 2019 (32 minutes), but spent significantly shorter to do so in July 2020 (22 minutes) versus July 2019 (42 minutes). Screening coverage was significantly less in March 2020 (241.75 hours) versus March 2019 (346.5 hours). Screening coverage was significantly greater in April 2020 (611.5 hours) and July 2020 (513.5 hours) versus April 2019 (470.5 hours) and July 2019 (404.25 hours), respectively. CONCLUSIONS There was a significant increase in the rate of incoming TBI cases to the ED during the COVID-19 pandemic, warranting continued enrollment with added safety measures. Additionally, refinement of internal processes improved the accuracy of data collection. As demonstrated in this study, researchers can leverage ongoing data collection to facilitate process improvements and evaluate the impact of unexpected global events on their research.
Background Traumatic brain injury (TBI) is one of the leading causes of death in pediatric patients. Continued recruitment of pediatric TBI participants into a biobank amidst the COVID-19 pandemic not only necessitates adaptive changes to traditional recruitment methods but also requires an evaluation of emergency department (ED) utilization by TBI-presenting patients. Objective The primary objective of this exploratory retrospective study was to evaluate pediatric TBI-related ED utilization during the pandemic. The secondary objective was to appraise the efficacy of the research team’s internal screening processes. Methods Potential participants (ie, individuals who met all inclusion criteria and would be approached by a consenter) were screened from an ED’s electronic health record system. Data regarding their visit were recorded in a Health Insurance Portability and Accountability Act–compliant manner, which were cleaned through Google Sheets. Cleaned data were then coded as either a screening variable or a hospital utilization variable to examine the effects of the pandemic on internal operations and hospital utilization patterns. The variables were compared between select months during the pandemic in 2020 to analogous months in 2019 in the R programming language via the two-sample Student t test and the Mann-Whitney-Wilcoxon rank-sum test. Results The sample (N=2321) consisted of 1245 entries from 2019 and 1076 entries from 2020. A significantly greater proportion of potential participants (P<.001) were identified in 2020 (222/633, 35.1%) than in 2019 (195/908, 21.4%). A significantly greater proportion of potential participants (P<.001) had a visit reason indicative of a TBI in 2020 (181/222, 81.5%) than in 2019 (103/195, 52.8%). A significantly greater proportion of these injuries (P=.02) occurred inside (39/181, 21.5%) in 2020 than in 2019 (11/103, 10.7%). No significant difference was found across the mechanism of injury categories reported for potential participants between 2019 and 2020. Potential participants were significantly older (P=.006) in 2019 (mean 8.93 years) than in 2020 (mean 7.31 years). Screeners spent significantly longer (P=.03) to identify potential participants in March 2020 (55 minutes) than in March 2019 (32 minutes), but spent significantly less time (P=.01) to do so in July 2020 (22 minutes) than in July 2019 (42 minutes). Screening coverage was significantly lower (P<.001) in March 2020 (241.8 hours) than in March 2019 (346.5 hours). Screening coverage was significantly greater (P<.001) in April 2020 (611.5 hours) and July 2020 (513.5 hours) than in April 2019 (470.5 hours) and July 2019 (404.3 hours), respectively. Conclusions There was a significant increase in the rate of incoming TBI cases to the ED during the COVID-19 pandemic, warranting continued enrollment with added safety measures. Additionally, refinement of internal processes improved the accuracy of data collection. As demonstrated in this study, researchers can leverage ongoing data collection to facilitate process improvements and evaluate the impact of unexpected global events on their research.
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