A water-stable 3D luminescent metal-organic framework (MOF), [EuZn(μ-OH)(NDC)(HO)] (1), constructed from heterometallic [EuZn] clusters and electron-rich π-conjugated 1,4-naphthalenedicarboxylic acid (HNDC) ligands exhibits highly sensitive, selective, and reversible detection of ronidazole, which represents the first example of luminescent MOFs based on Ln-TM heterometallic clusters for the detection of antibiotics in aqueous solution.

The design and development of self-calibrating ratiometric luminescent sensors for the fast, accurate, and sensitive discrimination and determination of pollutants in wastewater is highly desirable for public and environmental health. Herein, a 3D porous Tb(III)-based metal−organic framework (MOF), {[Tb-(HL)(H 2 O) 2 ]•x(solv)} n (1), was facilely synthesized using a ureafunctionalized tetracarboxylate ligand, 5,5′-(((1,4-phenylenebis-(azanediyl))bis(carbonyl))bis(azanediyl))diisophthalic acid (H 4 L). The activated framework showed a good water stability in both aqueous solutions at a wide pH range of 2−14 and simulated antibiotic wastewaters. Interestingly, this Tb-MOF exhibited dual luminescence owing to the partial energy transfer from the antenna H 4 L to Tb 3+ . More importantly, activated 1 (1a) that was dispersed in water showed a fast, accurate, and highly sensitive discrimination ability toward antibiotics with a good recyclability, discriminating three different classes of antibiotics from each other via the quenching or enhancement of the luminescence and tuning the emission intensity ratio between the H 4 L ligand and the Tb 3+ center for the first time. Simultaneously, 1a is a ratiometric luminescent sensor for the rapid, accurate, and quantitative discrimination of D 2 O from H 2 O. Furthermore, this complex was successfully used for the effective determination of antibiotics and D 2 O in real water samples. This work indicates that 1a represents the first ever MOF material for the discriminative sensing of antibiotics and D 2 O in H 2 O and promotes the practical application of Ln-MOF-based ratiometric luminescent sensors in monitoring water quality and avoiding any major leak situation.

A water-stable homochiral luminescent metal-organic framework (HLMOF), {[Cd(l)(4,4'-bipy)]·DMA·5H2O}n (1), was obtained by a spontaneous symmetry-breaking crystallization from achiral precursors without any enantiopure auxiliary. The homochirality of 1 was confirmed by single-crystal X-ray diffraction and CD spectroscopy. Complex 1 exhibits an interesting enantioselective sensing of d/l-penicillamine in water.

The widespread of organic and inorganic pollutants in water from various industries, are responsible for serious environmental problems meanwhile represent a danger for human being. Therefore, the search of effective...

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Detecting biomarkers associated with diseases has significant meaning for early prevention, diagnosis, and treatment of diseases. The development of luminescent biosensors for rapid and accurate detection in real urine and serum is urgently desired for human health monitoring. Herein, a luminescent cadmium metal−organic framework, {[Cd(L)(bpbix)]•x(solv)} n (1), was successfully prepared by using a urea-functionalized dicarboxylate ligand, 5-(3-(pyridin-4-yl)ureido)isophthalic acid (H 2 L), 4,4′bis((1H-imidazol-1-yl)methyl)biphenyl (bpbix), and the Cd 2+ ion. The structure of 1 presents a 2-fold interpenetrating threedimensional pillared-layer framework. The complex 1 exhibits good stability in different-pH aqueous solutions and physiological fluids. Strikingly, the complex 1 shows quick response, high sensitivity, good anti-interference performance, and a recyclable ability for simultaneous sensing of hippuric acid (HA), nucleoside phosphates, and Fe 3+ in water. More significantly, this sensor can realize the sensitive and accurate detection of HA, nucleoside phosphates, and Fe 3+ in real urine and serum and meet the practical detection needs in clinical diagnosis. These results indicate that the complex 1 as a multiresponsive luminescent biosensor possesses great potential for practical detection of HA, nucleoside phosphates, and Fe 3+ in biological samples.

Rapid and accurate determination of biomarkers of human poisoning in real urine is of great significance for the assessment of health status. Herein, a luminescent urea-functionalized metal-organic framework (MOF), {[Cd(L)0.5(bpbix)]•x(solv)}n...