Lupeol inhibited high-glucose-induced apoptosis in NPCs by enhancing the anti-oxidative stress in the mitochondria. This study suggested lupeol as a potential therapeutic drug for treating intervertebral disc degeneration under hyperglycaemic conditions. These slides can be retrieved under Electronic Supplementary Material.
Background
Ewing sarcoma, the second most frequent bone tumor in children and adolescents, is often presented with localized disease or metastatic-related symptoms. In this study, we aim to construct and validate a nomogram for patients with Ewing sarcoma to predict the 3- and 5-year overall survival (OS) based on the Surveillance, Epidemiology, and End Results (SEER) database.
Methods
Demographic and clinic pathological characteristics of patients with Ewing sarcoma diagnosed between 2010 and 2015 were extracted from SEER database. Univariate and multivariate Cox analyses were carried out to identify the independent characteristics. The independent factors were further included into the construction of a nomogram. Finally, c-index and calibration curves were used to validate the nomogram.
Results
A total of 578 patients were enrolled into our analysis. The results of univariate Cox analysis showed that age, 7th AJCC stage, 7th AJCC T stage, 7th AJCC N stage, 7th AJCC M stage, metastatic status to lung, liver and bone were significant factors. Multivariate Cox analysis was performed and it confirmed age, N stage and bone metastasis as independent variables. Next, a nomogram was constructed using these independent variables in prediction to the 3- and 5-year OS. Furthermore, favorable results with c-indexes (0.757 in training set and 0.697 in validation set) and calibration curves closer to ideal curves indicated the accurate predictive ability of this nomogram.
Conclusions
The individualized nomogram demonstrated a good ability in prognostic prediction for patients with Ewing sarcoma.
The objective of this study was to investigate the therapeutic effects of diclofenac sodium nanoparticles and traditional placebo on Knee Osteoarthritis (KOA). 80 KOA patients admitted to the Inpatient Department of Orthopedics of Sunshine Union Hospital from June 2020 to July 2021 were selected, and divided into 40 cases using diclofenac sodium nano flexible liposomes topically (study group) and 40 cases using conventional placebo topically (control group). The two groups were compared for knee swelling, knee pain, and knee function scores before treatment, on the 3rd, 7 th , and 14 th days after treatment, and the incidence of adverse events during treatment was recorded. It was found that the knee swelling scores of the study group were significantly lower than those of the control group on the 7th and 14th days after treatment, and that the knee pain score of the study group was significantly lower than that of the control group at the 7th day after treatment, and that the knee joint mobility disorder scores of the study group were significantly lower than those of the control group at the 7th and 14 th days after treatment. The total effective rate of the study group was 85.0% (34/30), which was higher than that of the control group (12.5% (5/30)) (P<0.05). In conclusion, local application of diclofenac sodium nano flexible liposomes showed a stronger effect on KOA than traditional placebo, and no significant adverse reactions occurred.
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