Bone marrow stromal cells (MSCs) are a useful source of stem cells for the treatment of various brain injury diseases due to their abundant supply and fewer ethical problems compared with transplant treatment. However, the clinical application of MSCs is limited due to allograft rejection and immunosuppression in the process of MSCs transplantation. According to previous studies, microglial cell autophagy occurs following co-culture with MSCs. In the present study, exosomes were obtained from MSCs and subsequently characterized using transmission electron microscopy, atomic force microscopy and dynamic light scattering particle size analysis. The type of microRNAs (miRs) found in the exosomes was then analyzed via gene chip. The results demonstrated that microglial cell autophagy could be induced by exosomes. This mechanism was therefore investigated further via reverse transcription-quantitative PCR, western blotting and luciferase assays. These results demonstrated that exosomes from MSCs could induce microglial cell autophagy through the miR-32-mediated regulation of disabled homolog 2-interacting protein, thus providing a theoretical basis for the clinical application of miRs in MSCs.

CaO–Al2O3–MgO–SiO2 (CAMS)‐based glass‐ceramics were prepared using body crystallization method. Adding Cr2O3 into the ceramics not only effectively lowered the crystallization temperature, but also led to significant grain refinement of diopside that crystallized in the CAMS glass‐ceramic after crystallization treatment at 900°C for 2 hours. Experimental work verified that the epitaxial growth of the diopside on the spinel particles, which formed during nucleation treatment when fabricating the glass‐ceramics, facilitated the heterogeneous nucleation of diopside on the spinel and refined the diopside. In addition, two energetically favored crystallographic orientation relationships between the epitaxial growth diopside and spinel were experimentally observed. They are false[true1false¯12false]spinel//[001]diopside,//false(1true1false¯1false)spinel//(200)diopside and [1¯12]normalspinelfalse]//[101]diopside, (311)spinel//false(true131false¯false)diopside. These two novel results can be potentially used to develop new glass‐ceramic materials with improved performance.