Giant cell tumor of soft parts is a rare tumor that is clinically and histologically similar to giant cell tumor of the bone. We present a 53-year-old female with a giant cell tumor of low malignant potential arising from the neck. The clinicopathological features and the importance of immunohistochemistry in the differential diagnosis with other giant cell rich tumors was discussed.
Key Words: Soft tissue neoplasms, Giant cell tumors, Head and neck neoplasms
ÖZYumuşak dokunun dev hücreli tümörü, kemiğin dev hücreli tümörüne klinik ve histolojik olarak benzeyen, nadir görülen bir tümördür. Burada, 53 yaşındaki kadın hastada boyunundan köken alan düşük malign potansiyelli dev hücreli tümör olgusu sunuldu. Klinikopatolojik özellikleri ve diğer dev hücreden zengin tümörlerden ayırıcı tanısında immünohistokimyanın önemi tartışıldı.Anahtar Sözcükler: Yumuşak doku tümörleri, dev hücreli tümörler, Baş boyun tümörleri
Rhabdoid tumor (RT) is an uncommon childhood neoplasm that typically arises within the kidney. It is characterized by an aggressive clinical course. Since its description in 1978, several cases of primary extrarenal RT, including a CNS localization, have been reported. The first case in the CNS was reported in 1985 and was defined as "rhabdoid tumor" initially, and was classified as grade IV in the most recent classification of the World Health Organization under the term of "atypical teratoid/rhabdoid tumor". Nearly 200 cases of atypical teratoid/rhabdoid tumor of the CNS have been reported to date, most of them occurring in childhood. We report a case of primary RT of the brain located in the right frontal lobe with the clinical, radiographic and pathological features presenting at an unusual age. This tumor, which was composed purely of rhabdoid cells with no additional primitive neuroectodermal, epithelial and mesenchymal components, was in a 27-year-old male patient. In conclusion, RT should be considered also in the differential diagnosis of intracerebral neoplasms of adult patients.
Malignant peripheral nerve sheath tumor (MPNST) of the urinary bladder is a very rare clinical entity. The association of such a tumor with urothelial carcinoma is even more unusual. Differential diagnosis between coexisting two distinct primary tumors and carcinosarcoma of the urinary bladder is very important as both the treatment and prognosis vary widely. Herein, we report a case of an MPNST with a concomitant in situ urothelial carcinoma in a 53-year-old man. To our knowledge, this is the first documented case of MPNST of the bladder that is treated by transuretheral resection which is in contrast with the previous reports that used cystectomy.
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