A new and efficient one-pot synthesis of polysubstituted pyrrole derivatives by three-component reaction between dialkyl acetylenedicarboxylates, triphenylphosphine, 2-aminopyridin derivatives in the presence of arylglyoxals is described. The reactions were performed in dichloromethane at room temperature and neutral conditions and afforded high yields of products.
A good yield in the stereospecific synthesis of S-vinylated mercapto groups in heterocyclic compounds is described involving the reaction of acetylenic esters and 2-mercapto-1-methylimidazole or 5-mercapto-1-methyltetrazole in the presence of pyridine. This one-pot method is simple and effective under mild conditions.
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