We have discovered and validated a panel of salivary exRNA biomarkers with credible clinical performance for the detection of GC. Our study demonstrates the potential utility of salivary exRNA biomarkers in screening and risk assessment for GC.

The research explores older women's clothing fit and style concerns and their attitudes toward 3D body scanning. A film of the 3D body scanning process was developed as an information source and shown to groups of older women prior to collecting survey and focus group data in 10 different community centers and living facilities in four Midwestern U.S. states. Clothing fit was the most important consideration to participants in making apparel purchasing decisions. Participants addressed the difficulty in finding clothing that fits their body shapes and styles that are appropriate for the aging body. Participants' preferences for using 3D body scanning in the future were also examined. Focus group participants expressed greatest willingness to use 3D body scanning for pattern development services. Future research needs to address older consumer acceptance of emerging technology applications for clothing customization and selection.

Prolyl hydroxylase (PHD) inhibitors are suggested as therapeutic agents for tissue regeneration based on their ability to induce pro-angiogenic responses. In this study, we examined the effect of the PHD inhibitor dimethyloxalylglycine (DMOG) on odontoblast maturation and sought to determine the underlying mechanism using MDPC-23 odontoblast-like cells. DMOG significantly enhanced matrix mineralization, confirmed by alizarin red staining and by measurement of the calcium content. DMOG dose-dependently increased alkaline phosphatase activity and the expressions of dentin sialophosphoprotein (Dspp) and osteocalcin. To determine the underlying events leading to DMOG-induced Dspp expression, we analyzed the effect of DMOG on Runx2. Knockdown of Runx2 using siRNAs decreased Dspp expression and prevented DMOG-induced Dspp expression. DMOG enhanced the transcriptional activity and level of Runx2 protein but not Runx2 transcript, and this enhancement was linked to the inhibitory effects of DMOG on the degradation of Runx2 protein. The vascular endothelial growth factor (VEGF) siRNAs profoundly decreased the Runx2 protein levels and inhibited the DMOG-increased Runx2 protein. Recombinant VEGF protein treatment significantly and dose-dependently increased the transcriptional activity and level of the Runx2 protein but not Runx2 transcript. Dspp expression was also enhanced by VEGF. Last, we examined the involvement of the Erk mitogen-activated protein kinase and Pin1 pathway in VEGF-enhanced Runx2 because this pathway can regulate the stability and activity of the Runx2 protein. VEGF stimulated Erk activation, and the inhibitors of Erk and Pin1 hampered VEGF-enhanced Runx2 protein. Taken together, the results of this study provide evidence that DMOG can enhance Dspp expression through VEGF-induced stabilization of Runx2 protein, and thus, suggest that DMOG can be used as a therapeutic tool for enhancing odontoblast maturation in dental procedures.

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Surface currents in Korean coastal regions were obtained using the maximum cross-correlation method applied to hourly suspended particulate matter images from the Geostationary Ocean Color Imager. Preliminary current vectors were filtered out by applying a series of quality-control procedures. The current vectors resulting from the tests were compared with the currents from a numerical model with tide and wind field. It was found that the estimated currents were more similarly to the currents caused by both tide and wind. A high degree of discrepancy was detected in regions of strong tidal currents, where the fundamental assumption of horizontal movement was limited due to the dominant vertical tidal mixing in the shallow region. The hourly rotations of the current vectors within a day were clarified by a comparison of the time-varying orientation angles of tidal ellipses. This study emphasized how to understand the short-term surface flows from hourly high-resolution geostationary satellite images. ARTICLE HISTORY

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Wi t hi n c r e a s i n gi n t e r e s t i nh e a l t hp r o mo t i o na n dq u a l i t yo fl i f e , g r o w i n ga t t e n t i o nh a sb e e nf o c u s e do nt h eb e n e f i c i a l e f f e c t so fu r b a ng r e e na r e a . Ho we v e r ,v e r yf e w e v i d e n c e -b a s e da p p r o a c h e sh a v eb e e nc o n d u c t e do nt h eh e a l t h -r e l a t e d b e n e f i t so f u r b a ng r e e n e r y . T h e r e f o r e , t h i ss t u d ye x a mi n e dt h eh e a l t h -r e l a t e db e n e f i t so f g r e e na r e a su s i n gp h y s i o l o g i c a l a n d