SUMMARY1. Gestation diets formulated to contain A, 9; B, 11; C, 13 or D, 15% protein, and lactation diets with C, 13 or E, 17% protein provided eight treatment combinations. They were given at seven centres at 2 kg/day in gestation and approximately 5·7 kg/day in lactation to sows which remained on experiment for three to five parities and produced in total 468 litters. Mean results for parities one to four are given in this summary.2. For gestation diets A to D mean litter size at birth was 9·7, 10·1, 10·3 and 10·4 live pigs, and at weaning (at 6 weeks), 8·2, 8·7, 8·8 and 8·8. Sows which received lactation diets C and E subsequently produced 10·4 and 10·3 pigs at birth and 8·9 and 8·3 at weaning.3. Gestation diets had no consistent effects on piglet weights. During lactation, however, diet E gave heavier pigs than C, by 0·2 kg at 3 weeks and 0·5 kg at weaning.4. Extra protein for either gestation or lactation had a positive effect on sow weight at that stage, but a negative effect in the following stage. There were no direct treatment effects on the time required for re-conception.5. Twenty experimental sows at the Rowett Institute, together with an additional group given diet A for both gestation and lactation, showed strong positive relationships between lactation protein intake and milk yield or composition.6. The treatment combination AC (i.e. 9% protein in gestation and 13% in lactation) gave the lowest weight of weaned pigs per litter, and CC gave the highest. The remaining treatments gave similar weights; of these BC (nominally 11 with 13, but actually 11·5 with 13·5% protein) was concluded to provide the lowest protein intake consistent with satisfactory performance.
ABSTRACT1. Gestation diets formulated to contain A, 9 or B, 11 % protein, and lactation diets with C, 13; D, 15; E, 17 and F, 19 % protein provided eight treatment combinations. They were given at 2 kg/day in gestation and approximately 5·7 kg/day in lactation to sows at eight centres, which remained on experiment for 3 to 5 parities and produced in total 529 litters. Mean results for parities 1 to 3 are given in this summary.2. Sows given more protein during gestation (i.e. diet A v. B) gained more weight in gestation (18·3 v. 22·5 kg net gain) but lost more in lactation (—1·7 v. —5·2 kg). Their offspring were significantly heavier at birth (1·31 v. 1·36 kg) and at 3 weeks old (5·28 v. 5·49 kg), but not at 6 weeks old (weaning).3. Giving more protein in lactation caused linear increases in piglet weights at 3 and 6 weeks, and a linear reduction in creep feed consumption. From a sample of sows whose milk yields were recorded, extra protein appeared to increase milk yield and its protein content. Extra protein for lactating sows also reduced their live-weight loss in lactation, but this effect was partially counterbalanced by smaller gains in gestation.4. No treatment had consistent significant effects on litter size or on the interval from weaning to conception. There were no significant interactions between gestation and lactation protein concentrations.5. The generally large differences between centres were in a few cases associated with centre × treatment interactions, but these were not such as to cast doubt on the general applicability of the main findings of the experiment.6. From this and an earlier experiment the minimum protein level for diets based on barley was concluded to be 11 % during gestation and 15% during lactation. For lactation diets, however, the economic optimum level may be > 15 %.
This study investigated the safety and functionality of a functional additive for humans and animals from Sargassum horneri (SH) and Ulva australis (UA) waste for recycling marine refuse generated in large quantities in Jeju. Sprague-Dawley rats were orally administered functional additives at 2,000 mg/kg to assess 14-day repeated dose toxicity of the two extracts. For female rats, weight gain after administration of SH was 66.2±18.8% vs. controls. Male rats administered UA showed weight gain of 92.3±8.0% vs. controls. SH and UA significantly decreased serum glucose levels in male rats compared with controls (79.8±11.10% and 76.1±9.67%, respectively). Similarly, significant decrease in serum glucose levels were shown for female rats after administration of SH and UA (79.2±1.58% and 82.8±3.21%, respectively). Furthermore, rats showed significant differences vs. controls in several serological parameters after receiving extracts, however results remained within the normal range. Thus, the SH and UA extracts were considered safe substances that may be used as functional additives to help reduce body weight and serum glucose.
Highlights Lipid accumulation in the 3T3-L1 cells were inhibited by treatment with DRE. The expression levels of SREBP1c , PPARγ, C/EBPα , and FAS were decreased by DRE. HFD induced fat mice showed lower rate of weight gain and serum TG level through DRE administration.
Current research highlights the use of natural products or phytochemicals as drugs and functional additives to treat obesity with few side effects. Sargassum horneri (SH) and Ulva australis (UA) are marine waste resources on Jeju Island, Republic of Korea. In this study, we analyzed their antioxidant and anti-obesity efficacies to confirm their potential as functional additives. We prepared SH and UA extracts using 80% ethanol and observed that free radical scavenging activity and total phenol content were high in SH extracts, and total flavonoid content was elevated in UA extracts. Additionally, 3T3-L1 cells were treated with SH and UA extracts, and the ability of the extracts to inhibit adipocyte differentiation was examined using Oil Red O staining and analysis of neutral fat content. We confirmed that the mRNA expression of the C/EBPα, PPARγ, and SREBP1c genes that act on adipocyte differentiation, and of FAS, a fatty acid synthase, was suppressed. Experiments in a mouse model of obesity showed that 12-week administration of a high-fat diet with 1% extract added to drinking water resulted in lower weight gain compared to the high-fat diet alone. These results suggest that SH and UA extracts have antioxidant properties and are effective in obesity prevention. Therefore, the two marine waste resources are potential functional additive candidates for preventing obesity.
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