Effects of Sargassum horneri and Ulva australis Extracts on Body Weight and Serum Glucose Levels of Sprague-Dawley Rats

Abstract

This study investigated the safety and functionality of a functional additive for humans and animals from Sargassum horneri (SH) and Ulva australis (UA) waste for recycling marine refuse generated in large quantities in Jeju. Sprague-Dawley rats were orally administered functional additives at 2,000 mg/kg to assess 14-day repeated dose toxicity of the two extracts. For female rats, weight gain after administration of SH was 66.2±18.8% vs. controls. Male rats administered UA showed weight gain of 92.3±8.0% vs. controls. SH and UA significantly decreased serum glucose levels in male rats compared with controls (79.8±11.10% and 76.1±9.67%, respectively). Similarly, significant decrease in serum glucose levels were shown for female rats after administration of SH and UA (79.2±1.58% and 82.8±3.21%, respectively). Furthermore, rats showed significant differences vs. controls in several serological parameters after receiving extracts, however results remained within the normal range. Thus, the SH and UA extracts were considered safe substances that may be used as functional additives to help reduce body weight and serum glucose.

Identification and characterization of a calcium-binding peptide from salmon bone for the targeted inhibition of α-amylase in digestion

“…With minor modifications based on the method ( Lee et al, 2023 ). 3 T3-L1 Preadipocytes were cultured at 37 °C and 5% CO 2 until 80% fusion, passaged and differentiated.…”

“…Lipid content was measured according to previous with minor modifications ( Lee et al, 2023 ). Differentiated cells were washed 3 times with PBS and subsequently fixed with formaldehyde.…”

Anti-Diabetic Potential of Sargassum horneri and Ulva australis Extracts In Vitro and In Vivo

“…Animals with blood glucose levels of 250 mg/dL were selected for this study. The ICR mice were divided into six groups: (1) normal, (2) diabetic, (3) metformin (100 mg/kg/day), (4) SH (500 mg/kg/day), and (5) UA (500 mg/kg/day) ( Scheme 1 ) [ 20 , 35 ]. The groups were fed the same diet and divided into six sub-groups of five animals each.…”

“…Sargassum horneri (SH), used in the present study, is a delicacy in East Asia, whereas Ulva australis (UA) is used as food in Europe. However, SH and UA have been identified as the main causes of coastal pollution on Jeju Island [ 19 , 20 ].…”

Potential anti‐obesity effects of fucoidan from Malaysian brown seaweed (Sargassum binderi) by in vivo study

“…In earlier research, fucoidan derived from Malaysian brown seaweed of Sargassum binderi was observed to display significant bioactive properties and be identified as safe for consumption and non-toxic (Lim et al, 2016). Besides, several recent studies reported the significant anti-obesity effects of fucoidan from different Sargassum species (Zuo et al, 2022;Lee et al, 2023Lee et al, , 2024. Thus, it was deemed prudent to convey these findings into further exploration of the health effects of undervalued Malaysian seaweed.…”