Ethnopharmacological relevance: Plants of the genus Euphorbia have long been used as traditional medicine in China, Europe, America, Turkey, India, Africa, Iran, and Pakistan for their great medicinal value and health benefits. Their stems, leaves, roots, latex are widely used to treat respiratory infections, body and skin irritations, digestive disorders, inflammatory infections, body pain, snake or scorpion bites, pregnancy, sensory disturbances, microbial and anti-cancer diseases. Objective: This review aimed to provide updated information on the genus Euphorbia, including traditional medicinal uses, valuation and exploitation of medicinal plants, phytochemistry, botanical characterization, pharmacological and toxicological research focused on the medicinal properties of several Euphorbias in particular their antibacterial, anti-tumor, and cell manifestations, in addition to the effect of each isolated bioactive molecule from these species and their pharmacological use including preclinical evaluation of new drugs. Materials and methods: This work was conducted using scientific databases such as: PubMed, Google scholar, Scopus, Science Direct, etc. In addition, ChemDraw software has been used for the drawing of chemical molecules. The correct names of the plants were confirmed from plantlist.org. The results of this review research were interpreted, analyzed and documented based on the bibliographical information obtained. Results: Among all the species of the Euphorbiaceae family, 15 species have been demonstrated to exhibit anticancer activity, 21 species have antibacterial activity and 10 species have cytotoxic activity. The majority of the chemical constituents of this plant include triterpenoid glycosides, diterpenoids, flavonoids, and the 4α-methyl steroids. Among them, the main bioactive constituents are present in the diterpenoid fraction. The study of more than 33 steroid plants identified more than 104 compounds. Pharmacological research proved that the crude extracts and some pure compounds obtained from Euphorbia had activities for the treatment of different diseases. The objective of the present study was focused on cytotoxic, antibacterial and antitumor diseases. The study of the phytochemistry of the Euphorbia families led to the conclusion that all the plants studied had active compounds, of which 27 plants characterized by their cytotoxic effects, 7 had antibacterial effects and 10 plants had anti-tumor activities. Therefore, the safety of Euphorbia herbal medicine should be considered a top priority in the early stages of development and clinical trials. Conclusions: Many previous studies have validated many traditional uses of Euphorbia species. The latex of some Euphorbia species seems to be toxic however studies dealing with safety and quality of these species are still incomplete. Extensive studies are needed on the Euphorbia plants before it can be fully used in clinics as a potent drug candidate, as researchers are focusing mainly on diterpenoids and triterpenoids, while there are many other types of compounds that may possess new biological activities.
In addition to producing bioenergy and molecules with high added value, microalgae have been recognized as an efficient microorganism for wastewater treatment. However, a major obstacle preventing its widespread use is the high energy cost of pretreatment, cultivation and downstream processes. Different types of wastewaters have been tested as culture mediums for microalgal biorefinery system. This review gives a summary of the most used microalgae strains for wastewater treatment, as well as information on the physical and chemical characteristics of domestic, agricultural, and industrial wastewaters. It also discusses wastewater pretreatment techniques, nutrient uptake and removal, biomass production and biomolecules productivities. There is also discussion on how microalgae remove contaminants from wastewater. Additionally, the problems and restrictions of microalgae-based wastewater treatment are explored, and recommendations are made for additional study and advancement. This literature review demonstrates that microalgae monoculture systems have proven to be beneficial as an innovative wastewater treatment technology, due to its high efficiencies in pollutant removals and biomolecule production; however, the upstream and downstream treatment pose a limit to industrialize the process. Until now, there has been no conventional design of the wastewater treatment process using microalgae in the biorefinery system, which constitutes a huge gap to assess a real life cycle assessment (LCA) and techno economic analysis (TEA).
aims: The goal of this study was to evaluate the antidiabetic effect of Rhamnus alaternus aqueous extract in streptozotocin(STZ)-induced diabetic rats. background: Traditionally, the aerial parts of Rhamnus alaternus L. have been widely used, in Mediterranean countries, including Morocco, for the cure of diabetes. objective: This work aimed to evaluate the antihyperglycemic effect of Rhamnus alaternus aqueous extract (RAAE) in normal and diabetic rats. Then the phytochemical composition, antioxidant capacity and the potential toxicity of RAAE were also assessed. method: The effects of the acute (6 h) and sub-chronic (7 days) oral administration of RAAE (20 mg/kg) on blood glucose levels and lipid profiles were evaluated in normal and diabetic rats. Besides, a preliminary phytochemical screening, quantification of phenolic, flavonoid and tannins contents as well as the antioxidant activity, using the DPPH method, were evaluated. Additionally, the toxicity of the aqueous extract (5 mg/kg) was also studied and the LD50 value was determined. result: RAAE (20 mg/kg) over 7 days of oral administration decreased significantly the blood glucose levels both in normal and diabetic rats. In diabetic rats, this extract was also able to improve oral glucose tolerance. In addition, RAAE possessed a significant antioxidant activity. According to preliminary phytochemical research, RAAE contains several chemical compounds, including alkaloids, polyphenols, flavonoids, cyanidins, anthraquinones and sterols. On the other hand, the quantitative phytochemical study of the aqueous extract revealed a considerable amount of total phenolic compounds (497.93±3.38 mg GAE/1 g of RAAE), flavonoids (100.42 ± 0.32 mg RE/ g of RAAE), and tannins (14.32 ± 0.37 mg CE/1g of RAAE). conclusion: We conclude that RAAE exerts a significant antihyperglycemic effect in STZ-induced diabetic rats at a low dose used. Indeed, more research is still required to support the use of this plant in the Moroccan population''s diabetes care. other: Not applicable
Background: Ammodaucus leucotrichus, Hypertension, L-NAME, Vasorelaxant, Angiotensin-converting enzyme-2(ACE2),sGC-cGMP, Vascular cyclooxygenase. Aims: The study aimed to determine the antihypertensive activity of Ammodaucus leucotrichus. Objective: The study aimed to investigate the antihypertensive and vasorelaxant activities of the aqueous extract of Ammodaucus leucotrichus fruits (ALAE) in rats. Material and Methods: ALAE was prepared to study its antihypertensive effect in L-NAME (Nω-L-arginine methyl ester)-induced hypertensive rats and its vasorelaxant activity in isolated thoracic aortas of rats. The acute and subchronic effects of ALAE on systolic, diastolic, mean arterial pressure, and heart rate (HR) were evaluated after oral administration of ALAE (60 and 100 mg/kg body weight) for 6 h for the acute experiment and over 7 days for the subchronic test. Isolated thoracic aortic rings were prepared to examine the vasorelaxant action of ALAE. Several common pharmacological agents were used to test potential pathways implicated in vasorelaxant action. Results: The results showed that ALAE reduced blood pressure parameters (systolic, mean, and diastolic blood pressure) in L-NAME-induced hypertension rats after repeated oral treatment over seven days without affecting normotensive rats. Furthermore, in thoracic aortic rings pre-contracted with epinephrine (EP) (10 µM) or KCl (80 mM), ALAE (0.250-1.625 mg/ml) showed a vasorelaxant effect. In isolated rat thoracic aortas, blockage of soluble guanylyl cyslase with blue methylene (p<0.01) partially decreased this vasorelaxant effect. In addition, blockage of the prostaglandin synthesis pathway with indomethacin (p<0.05) also reduced the vasorelaxant activity of ALAE. Pretreatment of aortic rings with glibenclamide, propanolol, L-NAME, MLN-4760, or nifedipine did not affect ALAE-induced vasorelaxation. Conclusion: Ammodaucus leucotrichusis a prescient medicinal plant, able to act as an antihypertensive agent. Moreover, the results suggest that the extract increased cGMP in NO-independent manner.
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