No abstract

The authors assessed vitamin A, and its protein carriers vitamins C and E in serum and dialysis fluid of 10 patients with chronic renal failure during 6-12 months of continuous ambulatory peritoneal dialysis. Vitamin A and its protein carriers and serum vitamin E were elevated throughout the long-term investigation of continuous ambulatory peritoneal dialysis despite the fact that vitamin A and its protein carriers have a relatively great peritoneal transfer and loss into the dialysis fluid. The oral dose of 200 mg of vitamin C per day, despite the great peritoneal transfer and loss into the dialysis fluid, prevented the development of hypovitaminosis C. Assessment of vitamins B1, B2 and B6 revealed that the supplementation with these vitamins is adequate for patients during continuous ambulatory peritoneal dialysis.

Platelet count did not significantly decrease after charcoal haemoperfusion in patients with acute poisoning and significantly decreased during regular dialysis treatment. Adherent platelets and leucocytes were found on the surface of granules after haemoperfusion using a scanning electron microscope. Decreased platelet count returned to the original level at 48 to 72 hours after charcoal haemoperfusion.

In the present study, the NMR spectroscopic features of trovafloxacin (TVA) mesylate, pefloxacin (PFX) mesylate dihydrate and ciprofloxacin (CIP) hydrochloride monohydrate were studied in DMSO-d 6 solution with the aim of investigating the effects of substituents and the type of salt on the NMR parameters of basic bicyclic fluoroquinolone and fluoronaphthyridone ring systems. For this purpose, the 1 H-and 13 C-one-and two-dimensional homo-and heteronuclear NMR methods were used. The analysis of 1 H-and 13 C-NMR spectra confirmed the structures of investigated fluoroquinolone salts. Relationships between 1 H-and 13 C-NMR chemical shifts of fluoronaphthyridone and fluoroquinolone ring systems, calculated molecular descriptors (MDs) and drug-likeness scores (DLSs), computed for monoprotonic cations of investigated fluoroquinolone salts (TVAH + , PFXH + and CIPH + ), were also explored. The topological polar surface area (TPSA), the parameter of lipophilicity (miLogP), the relative molecular mass (M r ) and the volume (V) of computed molecular descriptors (MDs), as well as the G protein-coupled receptor ligand-likeness (GPCR ligand-ls), the ion channel ligand-likeness (ICL-ls), the kinase inhibitor-likeness (KI-ls) and the nuclear receptor ligand-likeness (NRL-ls) were used in this study. The 1 H-NMR chemical shifts of protons in COOH, H5 and NH n + , as well as 13 C-NMR chemical shifts of C4, C5 and C11 shown to be good parameters in exploration of property-property and property-drug-likeness relationships for investigated fluoroquinolone salts. Thus, collinear relationships of 1 H-NMR chemical shifts of protons in COOH, H5 and NH n + with TPSA and miLogP, as well as with GPCR ligand-ls, KI-ls and NRL-ls were revealed (d, ppm H in COOH vs. TPSA, d, d, ppm H5 vs.