Towards a European Strategy for Medicines Research (2014–2020): The EUFEPS Position Paper on Horizon 2020

Gaspar, Rogério; Aksu, Buket; Cuiné, A.; Danhof, Meindert; Takač, Milena Jadrijević-Mladar; Lindén, Hans H.; Link, Andreas; Muchitsch, Eva-Maria; Wilson, Clive G.; Öhrngren, Per; Dencker, Lennart

doi:10.1016/j.ejps.2012.09.020

Cited by 32 publications

(18 citation statements)

References 7 publications

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“…In the presented considerations, the rule that the potential of society lies in the proposed innovation and competitive solutions of public organizations providing services in the area of healthcare for chronically ill patients [11,13]. In the present analysis it was adopted that the social responsibility of the person for his/her health (as the hypothetical patient) increases through direct participation in the control of his/ her own health because of its internal or external location.…”

Section: The Specificity Of System Solutions In Chronic Diseasesmentioning

confidence: 99%

Healthcare model with use of information and communication technology for patients with chronic disease

Lisiecka-Biełanowicz

Wawrzyniak

2016

Ann Agric Environ Med.

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Introduction and objective. The healthcare system is positioned in the patient's environment and works with other determinants of the treatment. Patient care requires a whole system compatible to the needs of organizational and technical solutions. The purpose of this study is to present a new model of patient-oriented care, in which the use of information and communication technology (ICT) can improve the effectiveness of healthcare for patients with chronic diseases. Material and methods. The study material is the process of healthcare for chronically ill patients. Knowledge of the circumstances surrounding ecosystem and of the patients' needs, taking into account the fundamental healthcare goals allows us to build a new models of care, starting with the economic assumptions. The method used is modeling the construction of efficient healthcare system with the patient-centered model using ICT tools. Results. We present a new systemic concept of building patient's environment in which he is the central figure of the healthcare organization-so called patient centered system. The use of ICT in the model of chronic patient's healthcare can improve the effectiveness of this kind of care. The concept is a vision to making wide platform of information management in chronic disease in a real environment ecosystem of patient using ICT tools. Conclusions. On the basis of a systematic approach to the model of chronic disease, and the knowledge of the patient itself, a model of the ecosystem impacts and interactions through information feedback and the provision of services can be constructed. ICT assisted techniques will increase the effectiveness of patient care, in which nowadays information exchange plays a key role.

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Section: The Specificity Of System Solutions In Chronic Diseasesmentioning

confidence: 99%

Healthcare model with use of information and communication technology for patients with chronic disease

Lisiecka-Biełanowicz

Wawrzyniak

2016

Ann Agric Environ Med.

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“…(1) Organ or tissue targeting (Rowland et al, 2012) (2) Biochemical protection of drug with increased stability and lower toxicity (Mishra et al, 2013) (3) Absence of adverse interactions with biological surroundings (Rowland et al 2012) (4) Long circulation lifetime (Mishra et al, 2013) (5) Biodegradability (Mishra et al, 2013) (6) Easy and low-cost production (Gaspar et al, 2012) (7) Long storage lifetime (Duncan & Gaspar, 2011).…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

“…Pharmaceutical Nanotechnology and Nanomedicine have branched out in different directions, each of them embodying the key insight that the ability to structure materials, devices and systems at the molecular scale can bring enormous immediate benefits in the research of drug delivery systems (DDS) and diagnostic methods (Hughes, 2005;Ravichandron, 2009;Mishra et al, 2010;Souza et al, 2010;Doane & Burda, 2012;Gaspar et al, 2012). Pharmaceutical nanotechnology is oriented in the area of targeted drug delivery, especially in colloidal nanocarriers and can offer solutions and benefits in many areas such as:…”

Section: Introductionmentioning

confidence: 99%

Advanced drug delivery nanosystems (aDDnSs): a mini-review

Demetzos¹,

Pippa²

2013

Drug Delivery

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Significant progress has been made in nanoscale drugs and delivery systems employing diverse chemical formulations to facilitate the rate of drug delivery and to improve its pharmacokinetics. Biocompatible nanomaterials have been used as biological markers, contrast agents for imaging, healthcare products, pharmaceuticals, drug-delivery systems as well as in detection, diagnosis and treatment of various types of diseases. The classification of drug delivery nanosystems (DDnSs) is a crucial issue and fundamental efforts on this subject are missing from the literature. This article deals with the classification of DDnSs with a modulatory controlled release profile (MCR) denoted as modulatory controlled release nanosystems (MCRnSs). Conventional (c) and advanced (a) DDnSs are denoted by the acronyms cDDnSs and aDDnSs, and can be composed of a single or more than one biomaterials, respectively. The classification was based on their characteristics such as: surface functionality (f), the nature of biomaterials used and the kind of interactions between biomaterials. The aDDnSs can be classified as hybridic (Hy-) or chimeric (Chi-) based on the nature -same or different respectively -of biomaterials and inorganic materials used. The nature of the elements used for producing advanced biomaterials is of great importance and medicinal chemistry contributes effectively to the production of aDDnSs.

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“…It is obvious that, for continuous processing, real-time quality control is indispensable, so the need to invest in process analytical technology (PAT) is strengthened. With the Horizon 2020 framework program for research and innovation in mind, the European Federation for Pharmaceutical Sciences (EUFEPS) also highlighted the need for appropriate in-line measurements, in order to make possible lean continuous manufacturing [3]. This review aims at summarizing the status of the implementation and the suitability of PAT tools for continuous pharmaceutical manufacturing processes of conventional solid-dosage forms, focusing on opportunities and shortcomings.…”

Section: Introductionmentioning

confidence: 99%

Process Analytical Technology for continuous manufacturing of solid-dosage forms

Fonteyne

Vercruysse

Leersnyder

et al. 2015

TrAC Trends in Analytical Chemistry

142

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Currently, pharmaceutical production is making the switch from batch processing towards continuous processing. The quality of intermediate and end products produced by batch processes is assured by off-line testing. It is obvious that off-line tests in analytical laboratories cancel out the advantages of continuous processing, so the critical quality attributes of continuously produced pharmaceuticals need to be monitored in real time. In 2004, the US Food and Drug Administration launched the process analytical technology (PAT) concept to stimulate the pharmaceutical industry to change from off-line to real-time quality testing. This review explores the implementation of PAT tools within continuous pharmaceutical processes (i.e., blending, spray drying, roller compaction, twin-screw granulation and compression), focusing on both opportunities and challenges.

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Towards a European Strategy for Medicines Research (2014–2020): The EUFEPS Position Paper on Horizon 2020

Cited by 32 publications

References 7 publications

Healthcare model with use of information and communication technology for patients with chronic disease

Healthcare model with use of information and communication technology for patients with chronic disease

Advanced drug delivery nanosystems (aDDnSs): a mini-review

Process Analytical Technology for continuous manufacturing of solid-dosage forms

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