396). When we compared differences between endoscopic scores at the time points of 12 months and six months postoperatively (ESt12 minus ESt6), we found statistically lower differences in the clarithromycin-surgery group than in the surgery group (p = 0.006).
Conclusion: Preoperative clarithromycin administration postponed nasal polyp relapse after FESS. Allergies have no influence on the clinical efficacy of clarithromycin therapy and on the efficacy of FESS.Keywords: Clarithromycin, long term, low dose, nasal polyposis, surgical procedures
Efectos de la Administración de Claritromicina Preoperatoria en Pacientes con Poliposis Nasal
Background:Pott’s puffy tumour is characterized by a fluctuate swelling of the frontal region as a result of osteomyelitis of the frontal bone. This inflammatory lesion may propagate endocranially, resulting in acute meningitis, epidural abscess, subdural empyema, cavernous sinus trombophlebitis, cerebritis, and frontal lobe abscess of the brain.Case Report:We present an unusual case of a 33-year-old man suffering from Pott’s puffy tumour whose condition was further complicated by a draining epidural-cutaneous fistula and an epidural abscess. We confirmed the diagnosis by contrast-enhanced computed tomography scanning and magnetic resonance imaging of the head. After intense antibiotic treatment, we performed a combined endoscopic and external surgical approach with drainage of abscesses, evacuation of pus and bone sequestrate and excision of fistulous lesion. The treatment was prolonged with four weeks’ antibiotic administration.Conclusion:Subperiosteal abscess of the frontal bone is an extremely rare complication of frontal sinusitis. This lesion may propagate endocranially, resulting in dangerous intracranial inflammatory lesions. Early diagnosis, medication and surgical therapy are very important in reducing morbidity and mortality.
Serum cytokines level cannot be used as laryngeal squamous cell carcinoma markers. Progression from T1-2 to T3-4 stage is followed by decreased serum interleukin-12 levels and increased interleukin-10 levels. Nodal involvement is associated with lower serum interleukin-12 levels. In patients with early stage tumours, serum interleukin 6, 10, 12 and 13 concentrations are significantly higher in those with supraglottic vs glottic tumours.
The MMA with mucocele marsupialization abolishes middle meatal obstruction and establishes better drainage and ventilation of the maxillary sinus and restitution of its mucosa.
Chondromesenchymal hamartoma (CMH) is a rare, benign lesion of the nasal cavity, paranasal sinuses, and skull base, composed of islands of hyaline cartilage in a myxoid background. The vast majority of CMH cases are infants and young children. According to the world literature, nasopharyngeal involvement of CMH is extremely rare. In all cases, the lesions were masses protruding from the nasal cavity or paranasal sinuses to the nasopharynx. We hereby report 2 adult male patients with masses completely situated in the nasopharyngeal space. In the first patient, the tumor originated from the posterior edge of the nasal septum and in the second one, from the posterolateral wall of the nasopharynx, adjacent to the pharyngeal orifice of the Eustachian tube. In both patients, the lesion was excised endoscopically, and histopathological analyses were consistent with a diagnosis of CMH. To our knowledge, those are the only cases of CMH completely situated in the nasopharynx.
There could be more than one potential delicate mechanism of developing EEC in the ear with VT insertion and mastoidectomy. It is necessary to perform routine otologic surveillance in all patients with tubes. Affected ear CT scan is very helpful in showing the extent of cholesteatoma and bony defects, which could not be assessed by otoscopic examination alone.
Introduction/Aim. Previous investigations suggest that matrix metalloproteinases (MMPs) have ability to degrade extracellular matrix components and play important role in malignant tumour progression and metastasis. The aim of this prospective study was to investigate matrix metalloproteinase-2 (MMP-2) and MMP-9 expression in tissue of laryngeal squamous cell carcinoma (LSCC) and to evaluate their clinical significance.
Methods. The samples of tumour tissue of seventy (n=70) patients with LSCC, 45 glottic and 25 supraglottic, and samples of laryngeal mucosa of 70 chronic laryngitis patients were immunohistochemically stained for MMP-2 and MMP-9. We studied the relationships between MMPs tissue expression and clinical and histological characteristics of LSCC in comparison to patients with chronic laryngitis. Results. MMP-2 and MMP-9 expression was significantly higher in tissue of both glottic and supraglottic SCC than in chronically inflamed laryngeal mucosa (p<0.001; p<0.001, respectively). There were positive correlations between epithelial MMP-2 expression and the presence of perineural invasion (r=0.515, p=0.008), lymphovascular invasion (r=0.559, p=0.004) and disease recurrence (r=0.415, p=0.039) in supraglottic SCC, as well as between MMP-2 expression and the presence of exophytic type of tumour growth (r=0.347, p=0.020) in glottic SCC. Epithelial MMP-9 expression is associated with lymphovascular invasion (r=0.331, p=0.026) and the presence of exophytic tumour growth (r=0.474, p=0.001) in glottic SCC. Conclusion. MMP-2 and MMP-9 can be used as potential biomarkers for assessment of LSCC progression.
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