Plasma immunoreactive insulin-like growth factor-l/somatomedin C (IR-IGF-I) was determined in rats fed for 1 week on a protein-free diet, or diets containing gluten, gluten supplemented with lysine and threonine, maize-gluten meal (with arginine), maize-gluten meal (with arginine) supplemented with tryptophan and lysine, or casein. IR-IGF-1 concentration was higher in the arterial plasma of rats fed on a diet containing casein at 120 g/kg diet (4-8 U/ml) than in rats fed on a protein-free or a low-casein (SO g/kg diet) diet (15-2 U/ml). The plasma of rats fed on gluten or maize-gluten meal as the protein source showed intermediate values. However, giving a diet containing an amino acid mixture as recommended by the National Research Council (1978) but deprived of lysine or tryptophan did not affect significantly the plasma IR-IGF-1 concentration. Total IGF-1 concentration (which was measured immunologically after extraction of the plasma with acid-ethanol) was also lower in the rats fed on the protein-free diet than in those fed on the casein (120 g/kg diet) diet. The ratio IR-IGF-I: total IGF-1 was higher in the rats fed on the casein diet (120 g casein/kg diet) than in those fed on the protein-free diet. The results suggest an important influence of IR-IGF-1 or IR-IGF-1:total IGF-1 ratio on protein anabolism and nutrition. IR-IGF-1 and total IGF-1 were found in the fractions of molecular weights 40 kDa and 150 kDa after gel filtration of rat plasma. A larger amount of IGF-1 was recovered in the fraction of 150 kDa in the rats fed on the casein diet. '"I-IGF-I added to the plasma of rats fed on the protein-free diet was found mainly in the fraction of 40 kDa after gel-filtration. On the other hand, '251-IGF-1 added to the plasma of rats fed on the gluten or casein diets was mainly recovered in the free IGF-I fraction. The results suggest that 1GF-binding protein@) of molecular weight about 40 kDa was not saturated with IGF-1 in the rats fed on the protein-free diet. The results indicate the important role of IGF-1 and its binding proteins in the regulation of protein metabolism in rats.
Ladies and gentlemen, this is the last session of the day, Session 4, a panel discussion of Finance to Ensure Asia's Economic Growth. My name is Masahiro Kawai, I am the Dean of the Asian Development Bank Institute, so I think we are going to focus on finance, growth and investment. As you know, in Asia there is a huge potential demand for investment. In particular, infrastructure investment needs are huge. The ADB and ADBI estimated that over the next 10 years, Asia would have to invest at least US$ 750 billion per year for infrastructure investment only.There are additional investment needs like environmental improvements, disaster risk management, and so forth. Also in the corporate sector, business needs huge
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