The present research has shown that ECG recordings and parameters of the body functional state are crucial for all kinds of the astronaut pre-flight preparations (centrifuge, thermal chamber, pressure chamber, pressure chamber with special equipment). It is, therefore, important to develop methods and tools for early detection of the preclinical forms of the functional state disorders in patients undergoing high-intensity loads of mixed character. The method based on the hardware-software compleх (HSC) with nanosensors of high resolution has been proposed to measure the electrophysiological characteristics and bioelectrical impedance of the body tissues directly exposed to loading. The hardware-software compleх is subjected to clinical trials in Tomsk Research Institute for Cardiology. The obtained results show that the use of nanosensors of high resolution in the HSC without standard filters allows elimination of the power-line interference in ECG recordings. Monitoring of the tissue bioimpedance parameters under test loads enables the detection of preclinical (latent) forms of various diseases. After clinical trials in Tomsk Institute for Cardiology the developed apparatus will be proposed for in-depth study of the cardiovascular system and the functional state of the body of astronauts and other persons exposed to extreme loads.
Implants made of porous SHS-TiNi alloys are successfully used in medicine to replace solid tissues of the human body. Self-propagating synthesis reaction of TiNi alloy was carried out through layer-by-layer combustion. XRD analysis of the phase composition and structural parameters of porous Ni50Ti50 alloy, as well as microscopic studies, were carried out. The structural methods employed in the study showed that the surface of porous SHS-TiNi alloys is a complex of dense layers of amorphous-nanocrystalline intermetallic oxycarbonitrides saturated with O, N, C intercalation impurities. The study of the surface layer S showed that the layer S consists of three layers: the foam layer F and two sublayers. Samples were studied for the nonuniform potential distribution in the cross section of interpore partitions. It was shown that they correlate with the structural phase inhomogeneity of the SHS-TiNi alloy. The structural studies carried out using different methods allowed us to reliably establish the presence of surface nonmetallic phases in the form of surface films and grain boundary inclusions formed during the self-propagating reaction synthesis of the porous TiNi alloy. High biochemical compatibility is ensured by specific surface layers of the porous alloy formed in the process of its metallurgy, which do not require additional surface modification.
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