The main types of normal sweat glands are eccrine and apocrine. The papillary eccrine adenoma is a rare, benign, sweat gland tumor. The clinical aspect is a slow growing solitary dermal nodule on the extremities, less frequently involving the trunk or face. Here it was described a case of papillary eccrine adenoma developed in the scapular-humeral region in a 72 years old man. The K5+/K7+/K8/18+/ K19+/SMA+/ S100+ immunohistochemical profile and the morphological aspects support the diagnostic of papillary eccrine adenoma. The immunohistochemical profile is useful for the differential diagnostic and may increase the diagnosis accuracy.