HLA-DRB6 is one of the human major histocompatibility complex (MHC) genes present in DR1, DR2, and DR10 haplotypes (approximately 26% of individuals). It shows several anomalies in human and non-human primates, including exon 2 stop codons (non-randomly grouped between codons 74 and 94) and a promoter region, and an exon 1 coming from an inserted retrovirus. It has been shown that not only chimpanzee but also human Mhc-DRB6 lack the usual 3' untranslated (UT) polyadenylation signal, and in the present work it was found that the human DRB6 gene coming from an HLA-DR2 haplotype is effectively transcribed after transfection in mouse L cells, and that HLA-DRB6 molecules may be expressed on the cell surface. DRB6 transcription level is remarkably lower in human than in chimpanzee. Moreover, their exons 1 (both taken from the 3'LTR region of a mammary tumor retrovirus) are also different; this shows that these viral insertions may be an important mechanism for different evolutionary changes in orthologous genes of different species. The pathways by which DRB6 molecules may be expressed on the membrane are unclear but other examples of truncated protein expression have also been described, even within the human major histocompatibility complex (i. e., in HLA-G). Finally, the presence of mature HLA-DRB6 mRNA molecules supports the notion that splicing may take place even in the absence of a canonical 3'UT polyadenylation signal.

Purpose Fashion retail companies typically exhibit short life-cycles, high volatility and low predictability. Therefore, their success is largely determined by the organisation’s flexibility and responsiveness. The purpose of this paper is to present a methodology to facilitate inventory control to minimise both shortages and excess inventory for a multi-product, multi-period finite time horizon inventory problem by using statistical and stochastic analysis. Design/methodology/approach The proposed methodology operates in two phases: the first phase consists on determining an aggregate plan (AP) that will be used for monitoring the behaviour of the items during the time horizon. This plan is obtained by statistically analysing historical data related to sales and inventory shortages and is used to determine a demand forecast during the time horizon that allows to handle with potential disruptions derived from real demand variations. Finally, supply replenishment policies are defined to facilitate the monitoring process during the second phase. For the second phase, the behaviour of real demand for every item is captured into a database and compared against its projected demand (from the AP). If needed, adjustments are made in the procurement of future deliveries to reduce the probability of having shortages and/or excess inventory. Findings A case study in a Mexican fashion retail company was conducted to assess the performance of the methodology. Results indicate that shortage in early periods can be reduced totally for certain products while, for others, the reduction is about 90.5 per cent. In addition, the incomes of the company were increased over 57 per cent. Research limitations/implications Even when the success of the methodology has been shown, cultural and behavioural factors were not considered. An extensive study is suggested to determine if these factors should be included to enhance the performance of the methodology. Practical implications A case study of a Mexican fashion retail company was conducted to assess the performance of the proposed methodology. The methodology is easy to implement and effectively and quickly responds to disruptions in the demand and it also significantly reduces the level of shortages while increasing sales and revenue for the company. Originality/value This paper proposes a methodology that is able to anticipate product’s behaviour from early weeks. Additionally, replenishment policies allow to quickly adjust future orders to guarantee the availability of items and minimise overstock.

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DRB6 has been found to be transcribed in human and apes. Promoter region and exon 1 come from a 5' LTR from a mammary tumour retrovirus. However, the putative protein structure would be very different to other DR molecules and it is doubtful that it may function as an antigen presenting molecule. Primate DRB6 alleles previously published together with the two new macaque sequences reported here support the existence of a strong selective pressure working on exon 2 to generate stop codons at the end of the exon (between codons 74 and 94) during at least 23 million years. The topology of dendrograms constructed with different primate DRB6 alleles supports the "trans-species" evolution proposed for MHC class I, class II and possibly C4 genes. Finally, DRB6, which is one of the oldest DRB genes, has been lost in the HLA-DRB3 (or DR52) group of haplotypes (DR3, DR5, DR6 and DR8) and a small DRB6 sequence is present at the exon 2 first hypervariable region of DRB4 (or DR53) gene, which is present in DR4, DR7 and DR9 haplotypes.

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