Our study raises the possibility that GC/MS-based profiling of amino acids and TCA cycle-related molecules is a useful early diagnostic tool for UC.

Our models demonstrated high performance and might lead to the development of a novel treatment selection method based on UC condition.

Cronkhite-Canada syndrome (CCS) is a rare nonhereditary syndrome characterized by gastrointestinal polyposis and ectodermal changes [1]. Although several treatments, such as steroids, are available, the prognosis is poor, with a 5-year mortality rate of 55 % [2]. A 57-year-old man, who suffered from alopecia, anorexia, severe diarrhea, dystrophic nail changes, and pigmentation on the hands, presented to our hospital.

opathy, X-linked (IPEX) syndrome, which is characterized by multi-organ autoimmunity. 2,3 The AIE-related 75 kDa antigen (AIE-75) and villin have been established as target antigens recognized by anti-enterocyte autoantibodies and detected in the sera of patients with IPEX syndrome. 4,5 Although intractable enteropathy is also associated with mutations in other Tregassociated genes such as CD25 and CTLA4, enterocyte antigens have not been identified. [6][7][8] We report a case of a 13-yearold girl with CTLA4 haploinsufficiency, who was positive for anti-AIE-75 autoantibody and was successfully treated with 6-mercaptopurine (6-MP). The written informed consent was waived by the ethics committee of our hospital.

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