Recent experimental study on Tsai-type quasicrystalline approximant Au-Al-Gd has revealed the presence of magnetic orders and phase transitions with changing the Au/Al concentration. Motivated by the experiment, we theoretically investigate whether a successive change of magnetic orders occurs in a minimal magnetic model including the RKKY interaction only. We find that the model induces multifarious magnetic orders depending on the Fermi wavenumber and gives a good starting point for understanding the experimental observation. In addition, we predict the presence of an undiscovered novel magnetic order called cuboc order at large Fermi wavenumber region.

Salts containing the merocyanine form of a pyridinium-fused spiropyran ([6′-MC]­X; X = I and PF6) were prepared, and their crystal structures were determined. In addition, the photochromic properties of the salts were spectroscopically and kinetically investigated. In the solution state, the salts exhibited negative photochromism. Theoretical calculations revealed that the negative photochromism of the salt originates from the drastic stabilization of the merocyanine structure by electron delocalization of the pyridinium ring. Furthermore, the salts containing the merocyanine and spiropyran forms ([6′-MC]­I, [6′-MC]­PF6, and [6′-SP]­PF6) were obtained by recrystallization. The crystals of [6′-SP]­PF6 exhibited positive photochromism in the solid state; however, no photochromism was observed in the [6′-MC]­X crystals.

Background and Aim: Upper gastrointestinal symptoms (UGSs), including reflux and dyspeptic symptoms (postprandial distress syndrome [PDS] and epigastric pain syndrome [EPS]), affect health-related quality of life. However, the influence of sex on the relationship between body mass index (BMI) and UGSs remains controversial. This study investigates the influence of sex on this association in healthy subjects. Methods and Results: We utilized the database of a prospective, multicenter, cohort study of 7112 subjects who underwent upper endoscopy for health screening. A multivariable logistic regression analysis was conducted to assess the association between BMI and UGSs stratified by sex, adjusting for clinical features. The influence of sex on the association between the overlapping of UGSs and BMI in symptomatic subjects was also investigated. Reflux symptoms were significantly associated with high BMI (multivariable odds ratio [OR] 1.36; 95% confidence interval [CI] 1.10-1.67, P = 0.004). PDS symptoms were significantly associated with low BMI (OR 2.37; 95% CI 1.70-3.25; P < 0.0001), but EPS symptoms were not associated with BMI. The association between reflux symptoms and higher BMI was limited to men (men: OR 1.40; 95% CI 1.10-1.77; P = 0.005, women: P = 0.40). sex did not influence the association between the presence of PDS symptoms and lower BMI. The percentage of overlapping of all three symptoms (reflux, PDS, and EPS) was higher in women than in men (19.9% [58/292] vs 10.5% [49/468], P = 0.0002). Conclusions: The influence of BMI on the presence of UGSs was significantly different according to sex in this large-scale cohort.

T-cell-specific Rap1 deletion causes spontaneous colitis in mice. In the present study, we revealed that Rap1 deficiency in T cells impaired the preceding induction of intestinal RORγt+ Treg cells. In the large intestinal lamina propria (LILP) of T-cell-specific Rap1-knockout mice (Rap1KO mice), Th17 cells were found to increase in a microbiota-dependent manner, and the inhibition of IL-17A production prevented the development of colitis. In the LILP of Rap1KO mice, RORγt+ Treg cells were scarcely induced by 4 weeks of age. The expression of CTLA-4 on Rap1-deficient Treg cells was reduced and the expression of CD80 and CD86 on dendritic cells was consequently elevated in Rap1KO mice. When cultured under each polarizing condition, Rap1-deficient naïve CD4+ T cells did not show biased differentiation into Th17 cells; their differentiation into Treg cells as well as Th1 and Th2 cells was lesser than that of wild-type cells. Rap1-deficient naïve CD4+ T cells were found to exhibit the defective nuclear translocation of NFAT and formation of actin foci in response to TCR engagement. These data suggest that Rap1 amplifies the TCR signaling required for Treg-mediated control of intestinal colitogenic Th17 responses.

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