The histologic lesion of follicular bronchiolitis may be seen as the predominant finding or a relatively minor feature in interstitial pneumonias. The clinical course and prognosis for most patients with follicular bronchiolitis is relatively good, and progressive lung disease is uncommon.
Pulmonary Langerhans cell histiocytosis (LCH) is an uncommon cause of interstitial lung disease. Corticosteroids and chemotherapeutic agents are frequently used to treat symptomatic patients but their efficacy is unclear. We describe a 66-year-old with biopsy-proven pulmonary and systemic LCH, whose pulmonary abnormalities responded dramatically to treatment with 2-chlorodeoxyadenosine (2-CdA). We propose that, in selected cases, 2-CdA should be considered in the management of pulmonary LCH.
These positive results, the reduction of pain and the satisfaction of the patients advocate the use of this prosthesis for the proximal interphalangeal joint. The postoperative ROM is comparable to those of other prostheses. Concerning implant loosening and swan-neck deformity, these results still offer room for improvement. Critical judgement and further development of the prosthesis design, the operation technique and the instrumentation are required to further optimise the results.
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