Nontraumatic Disruption of the Fibrocartilaginous Trachea

Aerni, Michelle R.; Parambil, Joseph G.; Allen, Mark S.; Utz, James P.

doi:10.1016/s0012-3692(15)51151-3

Cited by 16 publications

(10 citation statements)

References 20 publications

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“…The bronchoscopic appearance of the airway lesions included pseudomembrane formation, bronchial stenosis in the anastomosis line, ulcerations, and black eschar [47–49]. Severe complications may develop including a nontraumatic disruption of the anterolateral, fibrocartilaginous tracheal wall, as reported by Aerni et al [57]. The probable pathophysiologic basis for this complication was fungal invasion of the blood vessels resulting in a critical compromise of local blood supply [57].…”

Section: Trachobronchial Aspergillosismentioning

confidence: 99%

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Tracheobronchial Manifestations ofAspergillusInfections

Krenke

Grabczak

2011

The Scientific World JOURNAL

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Human lungs are constantly exposed to a large number of Aspergillus spores which are present in ambient air. These spores are usually harmless to immunocompetent subjects but can produce a symptomatic disease in patients with impaired antifungal defense. In a small percentage of patients, the trachea and bronchi may be the main or even the sole site of Aspergillus infection. The clinical entities that may develop in tracheobronchial location include saprophytic, allergic and invasive diseases. Although this review is focused on invasive Aspergillus tracheobronchial infections, some aspects of allergic and saprophytic tracheobronchial diseases are also discussed in order to present the whole spectrum of tracheobronchial aspergillosis. To be consistent with clinical practice, an approach basing on specific conditions predisposing to invasive Aspergillus tracheobronchial infections is used to present the differences in the clinical course and prognosis of these infections. Thus, invasive or potentially invasive Aspergillus airway diseases are discussed separately in three groups of patients: (1) lung transplant recipients, (2) highly immunocompromised patients with hematologic malignancies and/or patients undergoing hematopoietic stem cell transplantation, and (3) the remaining, less severely immunocompromised patients or even immunocompetent subjects.

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Section: Trachobronchial Aspergillosismentioning

confidence: 99%

“…Severe complications may develop including a nontraumatic disruption of the anterolateral, fibrocartilaginous tracheal wall, as reported by Aerni et al [57]. The probable pathophysiologic basis for this complication was fungal invasion of the blood vessels resulting in a critical compromise of local blood supply [57]. …”

Section: Trachobronchial Aspergillosismentioning

confidence: 99%

Tracheobronchial Manifestations ofAspergillusInfections

Krenke

Grabczak

2011

The Scientific World JOURNAL

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“…Surgical end-to-end anastomosis is recommended for patients with severe necrosis, pneumomediastinum, or pneumothorax (17). However, this procedure had limited benefit in our case because of the high risk associated with the operation (13).…”

Section: Discussionmentioning

confidence: 78%

“…The treatment for chondronecrosis of the distal trachea can be decided depending on the location, extent, and depth of the chondronecrosis as well as the condition of the tumor (13). For example, tracheomediastinal fistula in the form of small ulcers can be treated with antibiotics, corticosteroids, argon plasma coagulation, and fibrin glue (4,14).…”

Section: Discussionmentioning

confidence: 99%

Malignant tracheal necrosis and fistula formation following palliative chemoradiotherapy: a case report

Kim¹,

Koh²,

Kim³

et al. 2017

J. Thorac. Dis.

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Concurrent chemoradiotherapy is an essential treatment strategy for inoperable locally advanced non-small cell lung cancer (NSCLC). Although supportive care has improved, unexpected complications due to the disease or treatment can occur. Tracheomediastinal fistulas are very rare but can be a serious problem. Herein, we report a case of severe chondronecrosis of the distal trachea with formation of a fistula into a metastatic lymphadenopathy in a patient with stage IIIB NSCLC. The patient received external beam radiotherapy with a total dose of 35 Gy in 14 fractions, which was approximately half of the conventional therapeutic radiotherapy dose, along with concurrent cisplatin based chemotherapy. Careful evaluation, early detection, and timely intervention are essential to prevent and appropriately treat chondronecrosis, even in cases of low-dose radiotherapy application to central tumors.

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“…Die Entzündung kann sich zudem transmural ausbreiten und zu Ulzerationen im Bereich der Tra chealwand führen. Im Extremfall kann es dann zur Trachealruptur [1] oder zur (zu meist tödlichen) Arrosion großer Gefäße kommen [4].…”

Section: Introductionunclassified

Invasive pulmonale Aspergillose

Knüttgen

Kamp²,

Ströhlein³

et al. 2009

Anaesthesist

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Invasive pulmonary aspergillosis (IPA) is a life-threatening infection predominantly affecting immunocompromised patients, e.g. with acute leukemia. This case report demonstrates that IPA can also occur in non-neutropenic critically ill surgical patients. The case of a 63-year-old woman is reported, who developed IPA of the respiratory tract in the course of diffuse purulent peritonitis. First-line therapy with voriconazol failed to be effective. However, application of caspofungin, intensive kinetic therapy (including prone position) and airway management by interventional bronchoscopy enabled successful treatment of this severe complication.

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Nontraumatic Disruption of the Fibrocartilaginous Trachea

Cited by 16 publications

References 20 publications

Tracheobronchial Manifestations ofAspergillusInfections

Tracheobronchial Manifestations ofAspergillusInfections

Malignant tracheal necrosis and fistula formation following palliative chemoradiotherapy: a case report

Invasive pulmonale Aspergillose

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