Michele Goulart dos Santos scite author profile

Neurodegenerative diseases are characterized by the progressive loss of neurons in different regions of the nervous system. Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most prevalent neurodegenerative diseases, and the symptoms associated with these pathologies are closely related to the regions that are most affected by the process of neurodegeneration. Despite their high prevalence, currently, there is no cure or disease-modifying drugs for the treatment of these conditions. In the last decades, due to the need for the development of new treatments for neurodegenerative diseases, several authors have investigated the neuroprotective actions of naturally occurring molecules, such as resveratrol. Resveratrol is a stilbene found in several plants, including grapes, blueberries, raspberries, and peanuts. Studies have shown that resveratrol presents neuroprotective actions in experimental models of AD and PD, however, its clinical application is limited due to its rapid metabolism and low bioavailability. In this context, studies have proposed that structural changes in the resveratrol molecule, including glycosylation, alkylation, halogenation, hydroxylation, methylation, and prenylation could lead to the development of derivatives with enhanced bioavailability and pharmacological activity. Therefore, this review article aims to discuss how resveratrol derivatives could represent viable molecules in the search for new drugs for the treatment of AD and PD.

Desafios enfrentados pelos agentes comunitários de saúde na Estratégia Saúde da Família

Santos¹,

Ceretta²,

Schwalm³

et al. 2015

is

7

0

A pesquisa teve como objetivo conhecer os desafios enfrentados pelos Agentes Comunitários de Saúde (ACS) no processo de trabalho na Unidade de Estratégia Saúde da Família (ESF) de um município da Região Sul de Santa Catarina. Trata-se de uma pesquisa de abordagem qualitativa, do tipo descritivo-exploratória e de campo. Utilizou-se como instrumento de coleta de dados a entrevista semi-estruturada aplicada com sete ACS que atuam nas ESF. Utilizou-se para análise dos dados as categorias de análise preconizadas por Minayo. Os ACS ressaltaram as dificuldades enfrentadas para encontrar as pessoas em casa, o mau tempo, a distância entre uma casa e outra, os animais soltos, a precarização das estradas e as casas fechadas; além da vulnerabilidade social da microárea com casos de tráfico de drogas, a falta de infra-estrutura na comunidade e a ocorrência de doenças infecto-contagiosas. O ouvir atento com esclarecimento das dúvidas, dar atenção ao problema das famílias de forma discreta e com ética profissional são condutas dos ACS para o enfrentamento das dificuldades e desafios no processo de trabalho na ESF. O papel do enfermeiro no processo de trabalho do agente comunitário perpassa o esclarecimento de dúvidas e a resolução dos problemas encontrados em cada microárea.

Neuroprotective Effects of Resveratrol in In vivo and In vitro Experimental Models of Parkinson’s Disease: a Systematic Review

¹

,

Schimith

²

,

André‐Miral

³

et al. 2022

Ecological niche modeling of Schinus molle reveals the risk of invasive species expansion into biodiversity hotspots

Lemos

¹

,

Matielo

²

,

Marques

³

et al. 2019

An. Acad. Bras. Ciênc.

Invasive species need a closer look on the threats they may cause to the environment, mainly considering the scenario of climatic changes predicted for the next decades. Schinus molle is a pioneer tree native from South America, reported as an important invasive species in four continents. Using ecological niche modeling we show that a wide area over the world is propitious for S. molle establishment under current climatic conditions, including 14 of the 25 world's biodiversity hotspots. Current projections of climate changes suggest scenarios implying the rise of areas favorable for S. molle expansion. Therefore, particular attention should be taken in regions where it was introduced, while approaches for long-term intervention may be necessary for regions of S. molle natural occurrence if its expansion threatens other native species. However, the natural dynamic of the ecosystems should be studied and contemplated in such regions.

Polydatin as a therapeutic alternative for central nervous system disorders: A systematic review of animal studies

Schimith

¹

,

²

,

Arbo

³

et al. 2022

Phytotherapy Research

Polydatin, or piceid, is a natural stilbene found in grapes, peanuts, and wines. Polydatin presents pharmacological activities, including neuroprotective properties, exerting preventive and/or therapeutic effects in central nervous system (CNS) disorders. In the present study, we summarize and discuss the neuroprotective effects of polydatin in CNS disorders and related pathological conditions in preclinical animal studies. A systematic review was performed by searching online databases, returning a total of 110 records, where 27 articles were selected and discussed here. The included studies showed neuroprotective effects of polydatin in experimental models of neurological disorders, including cerebrovascular disorders, Parkinson's disease, traumatic brain injuries, diabetic neuropathy, glioblastoma, and neurotoxicity induced by chemical agents. Most studies were focused on stroke (22.2%) and conducted in male rodents. The intervention protocol with polydatin was mainly acute (66.7%), with postdamage induction treatment being the most commonly used regimen (55.2%). Overall, polydatin ameliorated behavioral dysfunctions and/or promoted neurological function by virtue of its antioxidant and antiinflammatory properties. In summary, this review offers important scientific evidence for the neuroprotective effects and distinct pharmacological mechanisms of polydatin that not only enhances the present understanding but is also useful for the development of future preclinical and clinical investigations.

Repositioning and development of new treatments for neurodegenerative diseases: Focus on neuroinflammation

Arbo

¹

,

Schimith

²

,

European Journal of Pharmacology

³

et al. 2022

Desafios enfrentados pelos agentes comunitários de saúde na Estratégia Saúde da Família

¹

,

Ceretta

²

,

Schwalm

³

et al. 2015

is

1

0

A pesquisa teve como objetivo conhecer os desafios enfrentados pelos Agentes Comunitários de Saúde (ACS) no processo de trabalho na Unidade de Estratégia Saúde da Família (ESF) de um município da Região Sul de Santa Catarina. Trata-se de uma pesquisa de abordagem qualitativa, do tipo descritivo-exploratória e de campo. Utilizou-se como instrumento de coleta de dados a entrevista semi-estruturada aplicada com sete ACS que atuam nas ESF. Utilizou-se para análise dos dados as categorias de análise preconizadas por Minayo. Os ACS ressaltaram as dificuldades enfrentadas para encontrar as pessoas em casa, o mau tempo, a distância entre uma casa e outra, os animais soltos, a precarização das estradas e as casas fechadas; além da vulnerabilidade social da microárea com casos de tráfico de drogas, a falta de infra-estrutura na comunidade e a ocorrência de doenças infecto-contagiosas. O ouvir atento com esclarecimento das dúvidas, dar atenção ao problema das famílias de forma discreta e com ética profissional são condutas dos ACS para o enfrentamento das dificuldades e desafios no processo de trabalho na ESF. O papel do enfermeiro no processo de trabalho do agente comunitário perpassa o esclarecimento de dúvidas e a resolução dos problemas encontrados em cada microárea.