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Analyses of AREDS2 data on natural history of GA provide representative data on GA evolution and enlargement. GA enlargement, which was influenced by lesion features, was relentless, resulting in rapid central vision loss. The genetic variants associated with faster enlargement were partially distinct from those associated with risk of incident GA. These findings are relevant to further investigations of GA pathogenesis and clinical trial planning.

We report on a new coarse tip distance adjustment and positioner for a scanning tunneling microscope, which was designed with ease of sample manipulation and UHV compatibility in mind. It has no mechanical connections in UHV and has been successfully used for measurements of microfaceted platinum surfaces in air and cleaved Si(111) surfaces under liquids.

This study replicates the results of previous natural history studies of eyes with DPED including the high rates of progression to late AMD and vision loss (regardless of progression to late AMD). The genetic associations are consistent with genes associated with AMD progression.