18 F-labeled prostate-specific membrane antigen (PSMA)-ligand PET has several principal advantages over 68 Ga-PSMA-11. The purpose of this retrospective study was to evaluate the frequency of non-tumor-related uptake and the detection efficacy comparing 68 Ga-PSMA-11 PET/CT and 18 F-PSMA-1007 PET/CT in recurrent prostate cancer (PC) patients. Methods: The study included 102 patients with biochemically recurrent PC after radical prostatectomy undergoing 18 F-PSMA-1007 PET/CT imaging. On the basis of various clinical variables, patients with corresponding 68 Ga-PSMA-11 PET/CT scans were matched. All PET/CT scans (n 5 204) were reviewed by 1 nuclear medicine physician. First, all PET-positive lesions were noted. Then, lesions suspected of being recurrent PC were differentiated from lesions attributed to a benign origin on the basis of known pitfalls and information from CT. For each region, the SUV max of the lesion with the highest PSMA-ligand uptake was noted. Detection rates were determined, and SUV max was compared separately for 68 Ga-PSMA-11 and 18 F-PSMA-1007. Results: In total, 18 F-PSMA-1007 PET and 68 Ga-PSMA-11 PET revealed 369 and 178 PSMA-ligand-positive lesions, respectively. 18 F-PSMA-1007 PET revealed approximately 5 times more lesions attributed to a benign origin than did 68 Ga-PSMA-11 PET (245 vs. 52 lesions, respectively). The benign lesions most frequently observed were ganglia, unspecific lymph node, and bone lesions, at a rate of 43%, 31%, and 24% for 18 F-PSMA-1007 PET and 29%, 42%, and 27% for 68 Ga-PSMA-11 PET, respectively. The SUV max of lesions attributed to a benign origin was significantly higher (P , 0.0001) for 18 F-PSMA-1007 PET. Further, a similar number of lesions was attributed to recurrent PC (124/369 for 18 F-PSMA-1007 PET and 126/178 for 68 Ga-PSMA-11 PET). Conclusion: The number of lesions with increased PSMA-ligand uptake attributed to a benign origin is considerably higher for 18 F-PSMA-1007 PET than for 68 Ga-PSMA-11 PET. This finding indicates the need for sophisticated reader training emphasizing known pitfalls and reporting within the clinical context.

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Religiöse Selbstmordattentäter machen uns sprachlos. Wie aus dem Nichts tauchen sie auf, scheinbar geistesgestörte, selbstherrliche Einzeltäter, die viele mit in den Tod reißen und sich am Ende selbst richten. Kulturelle Erklärungsmuster und biographische Analysen schlagen fehl. Die Frage, wie einer zum Terroristen wird, scheint nicht beantwortbar. Michael König untersucht Romane, Thriller und biographische Erinnerungen, in denen deutsche Gegenwartsautoren versuchen, dem undurchdringlichen Phänomen und seinen Urhebern näher zu kommen. Ergänzend zur literaturwissenschaftlichen Analyse berichten zehn Autorinnen und Autoren - unter ihnen Ulrike Draesner, Sherko Fatah, Gerhard Seyfried, Ulrich Peltzer und Michael Wildenhain - in Interviews über ihre Probleme beim Schreiben über Terroristen und den erzeugten Terror. Sie kennzeichnen ihre eigenen Texte als engagierte Literatur, die im Zuge von weltumspannenden Überwachungsmethoden und einer zunehmenden Beschneidung von Bürgerrechten wieder dezidiert politisch geworden ist. Gegen mediale Generalisierungen rücken sie das Individuum in den Mittelpunkt der literarischen Betrachtung. Denn Attentäter und Terroristen sind am Ende keine »Monster« oder »Gespenster«, sondern Menschen.

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