These results indicate that intensive-course 5FU plus low-dose leucovorin is effective in preventing tumor relapse and improving survival in patients with high-risk colon cancer. These benefits were seen with only six cycles of treatment, using low-dose leucovorin in combination with 5FU on a schedule convenient for outpatient administration.

There was no significant improvement in patient survival when chemotherapy was given for 12 months compared with 6 months. When chemotherapy was given for 6 months, standard 5-FU plus levamisole was associated with inferior patient survival compared with intensive-course 5-FU plus leucovorin plus levamisole. These data suggest that 5-FU plus levamisole for 6 months should not be used in clinical practice, whereas 6 months of treatment with 5-FU plus leucovorin plus levamisole is effective.

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This research reports on an experimental and numerical study of material failure in the electrode assemblies (i.e. "jelly roll" and/or "electrode stack") of lithium-ion batteries after local mechanical loading. Deformed cylindrical and pouch cells (i.e. lithium-ion polymer cells) were subjected to X-ray computed tomography (CT scanning) to detect location, size, and orientation of cracks that developed in the electrode assemblies at onset of short-circuit. An experimental program was completed to acquire properties of electrode-separator micro components of electrode assemblies in tension. This data was used for calibration of an anisotropic material model. Finite element models were developed for both cell types and a maximum strain criteria was used for element failure and deletion at short circuit. The models developed here predict the location of cracks in both pouch and cylindrical cells. The finite element models corroborated the CT scan regarding location and orientation of cracks formed in the electrode assemblies. In both pouch and cylindrical cells, cracks were found to initiate perpendicular to the transverse direction of the separator. Fig. 3 Simulation of the crack through element erosion using the two models for 18650 cell. 80372 | RSC Adv., 2015, 5, 80369-80380 This journal is