High-finesse optical cavities placed under vacuum are foundational platforms in quantum information science with photons and atoms. We study the vacuum-induced degradation of high-finesse optical cavities with mirror coatings composed of SiO₂-Ta₂O₅ dielectric stacks, and present methods to protect these coatings and to recover their initial low loss levels. For separate coatings with reflectivities centered at 370 nm and 422 nm, a vacuum-induced continuous increase in optical loss occurs if the surface-layer coating is made of Ta₂O₅, while it does not occur if it is made of SiO₂. The incurred optical loss can be reversed by filling the vacuum chamber with oxygen at atmospheric pressure, and the recovery rate can be strongly accelerated by continuous laser illumination at 422 nm. Both the degradation and the recovery processes depend strongly on temperature. We find that a 1 nm-thick layer of SiO₂ passivating the Ta₂O₅ surface layer is sufficient to reduce the degradation rate by more than a factor of 10, strongly supporting surface oxygen depletion as the primary degradation mechanism.

No abstract

We report and demonstrate a method for measuring the branching ratios of dipole transitions of trapped atomic ions by performing nested sequences of population inversions. This scheme is broadly applicable to species with metastable lambda systems and can be generalized to find the branching of any state to lowest states. It does not use ultrafast pulsed or narrow linewidth lasers and is insensitive to experimental variables such as laser and magnetic field noise as well as ion heating. To demonstrate its effectiveness, we make the most accurate measurements thus far of the branching ratios of both P 5 1 2 and P 5 3 2 states in 88 Sr + with sub-1% uncertainties. We measure 17.175(27) for the P 5 1 2 -S 5 1 2 branching ratio, 15.845(71) for P 5 3 2 -S 5 1 2 , and 0.056 09(21) for P 5 3 2 -D 4 5 2 . These values represent the first precision measurement for P 5 3 2 -D 4 5 2 , as well as ten-and thirty-fold improvements in precision respectively for P 5 1 2 -S 5 1 2 and P 5 3 2 -S 5 1 2 over the best previous experimental values.

Cannabinoids represent a promising class of compounds for developing novel therapeutic agents. Since the isolation and identification of the major psychoactive component Δ(9)-THC in Cannabis sativa in the 1960s, numerous analogues of the classical plant cannabinoids have been synthesized and tested for their biological activity. These compounds primarily target the cannabinoid receptors 1 (CB1) and Cannabinoid receptors 2 (CB2). This chapter focuses on CB1. Despite the lack of crystal structures for CB1, protein-based homology modeling approaches and molecular docking methods can be used in the design and discovery of cannabinoid analogues. Efficient synthetic approaches for therapeutically interesting cannabinoid analogues have been developed to further facilitate the drug discovery process.