Background: PARC sequesters p53 in the cytoplasm; dysregulation of p53 localization/function contributes to chemoresistance in OVCA. Results: Cisplatin promotes calpain-mediated PARC down-regulation, mitochondrial and nuclear p53 accumulation, and apoptosis in chemosensitive but not resistant OVCA cells. Conclusion: Dysregulation of calpain-mediated PARC processing promotes chemoresistance in OVCA cells. Significance: PARC down-regulation represents a novel strategy to prevent/reverse resistance to cisplatin-based chemotherapy.

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