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Improvements in dietary fat intake, exercise, and stress management were individually, additively and interactively related to coronary risk and psychosocial factors, suggesting that multicomponent programs focusing on diet, exercise, and stress management may benefit patients with CHD.

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High levels of insulin-like growth factor 1 (IGF-5 1

Aim: Climate change will likely lead to a significant redistribution of biodiversity in marine ecosystems. We examine the potential redistribution of a community of marine predators by comparing current and future habitat distribution projections. We examine relative changes among species, indicative of potential future communitylevel changes and consider potential consequences of these changes for conservation and management.Location: Southern Indian Ocean. Methods:We used tracking data from 14 species (10 seabirds, 3 seals and 1 cetacean, totalling 538 tracks) to model the habitat selection of predators around the Prince Edward Islands. Using random forest classifiers, we modelled habitat selection as a response to a static environmental covariate and nine dynamic environmental | 143 REISINGER Et al.

In a fast-changing world, polar ecosystems are threatened by climate variability. Understanding the roles of fine-scale processes, and linear and nonlinear effects of climate factors on the demography of polar species is crucial for anticipating the future state of these fragile ecosystems. While the effects of sea ice on polar marine top predators are increasingly being studied, little is known about the impacts of landfast ice (LFI) on this species community. Based on a unique 39-year time series of satellite imagery and in situ meteorological conditions and on the world's longest dataset of emperor penguin ( Aptenodytes forsteri ) breeding parameters, we studied the effects of fine-scale variability of LFI and weather conditions on this species' reproductive success. We found that longer distances to the LFI edge (i.e. foraging areas) negatively affected the overall breeding success but also the fledging success. Climate window analyses suggested that chick mortality was particularly sensitive to LFI variability between August and November. Snowfall in May also affected hatching success. Given the sensitivity of LFI to storms and changes in wind direction, important future repercussions on the breeding habitat of emperor penguins are to be expected in the context of climate change.

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Systematic literature reviews provide rigorous assessments of clinical, cost-effectiveness, and humanistic data. Accordingly, there is a growing trend worldwide among healthcare agencies and decision-makers to require them in order to make informed decisions. Because these reviews are labor-intensive and time consuming, we applied advanced analytic methods (AAM) to determine if machine learning methods could classify abstracts as well as humans. Literature searches were run for metastatic non-small cell lung cancer treatments (mNSCLC) and metastatic castration-resistant prostate cancer (mCRPC) . Records were reviewed by humans and two AAMs. AAM-1 involved a pre-trained data-mining model specialized in biomedical literature, and AAM-2 was based on support vector machine algorithms. The AAMs assigned an accept/reject status, with reasons for exclusion. Automatic results were compared to those of humans. For mNSCLC, 5820 records were processed by humans and 440 (8%) records were accepted and the remaining items rejected. AAM-1 correctly accepted 6% of records and correctly excluded 79%. AAM-2 correctly accepted 6% of records and correctly excluded 82%. The review was completed by AAM-1 or AAM-2 in 52 hours, compared to 196 hours for humans. Work saved was estimated to be 76% and 79% by AAM-1 and AAM-2, respectively. For mCRPC, 2434 records were processed by humans and 26% of these were accepted and 74% rejected. AAM-1 correctly accepted 23% of records and rejected 62%. AAM-2 correctly accepted 20% of records and rejected 66%. The review was completed by AAM-1, AAM-2, and humans in 25, 25 and 85 hours, respectively. Work saved was estimated to be 61% and 68% by AAM-1 and AAM-2, respectively. AAMs can markedly reduce the time required for searching and triaging records during a systematic review. Methods similar to AAMs should be assessed in future research for how consistent their performances are in SLRs of economic, epidemiological and humanistic evidence.