Background and Aims: Severe acute respiratory syndrome (SARS) is a virulent viral infection that affects a number of organs and systems. This study examined if SARS may result in cardiovascular complications. Methods and Results: 121 patients (37.5 (SD13.2) years, 36% male) diagnosed to have SARS were assessed continuously for blood pressure, pulse, and temperature during their stay in hopsital. Hypotension occurred in 61 (50.4%) patients in hospital, and was found in 28.1%, 21.5%, and 14.8% of patients during the first, second, and third week, respectively. Only one patient who had transient echocardiographic evidence of impaired left ventricular systolic function required temporary inotropic support. Tachycardia was present in 87 (71.9%) patients, and was found in 62.8%, 45.4%, and 35.5% of patients from the first to third week. It occurred independent of hypotension, and could not be explained by the presence of fever. Tachycardia was also present in 38.8% of patients at follow up. Bradycardia only occurred in 18 (14.9%) patients as a transient event. Reversible cardiomegaly was reported in 13 (10.7%) patients, but without clinical evidence of heart failure. Transient atrial fibrillation was present in one patient. Corticosteroid therapy was weakly associated with tachycardia during the second (x 2 = 3.99, p = 0.046) and third week (x 2 = 6.53, p = 0.01), although it could not explain tachycardia during follow up. Conclusions: In patients with SARS, cardiovascular complications including hypotension and tachycardia were common but usually self limiting. Bradycardia and cardiomegaly were less common, while cardiac arrhythmia was rare. However, only tachycardia persisted even when corticosteroid therapy was withdrawn.

Differential Scanning Calorimetry (DSC) is a highly sensitive technique to study the thermotropic properties of many different biological macromolecules and extracts. Since its early development, DSC has been applied to the pharmaceutical field with excipient studies and DNA drugs. In recent times, more attention has been applied to lipid-based drug delivery systems and drug interactions with biomimetic membranes. Highly reproducible phase transitions have been used to determine values, such as, the type of binding interaction, purity, stability, and release from a drug delivery mechanism. This review focuses on the use of DSC for biochemical and pharmaceutical applications.

<div>The Drug Design Data Resource (D3R) aims to identify best practice methods for computer aided drug design through blinded ligand pose prediction and affinity challenges. Herein, we report on the results of Grand Challenge 4 (GC4). GC4 focused on proteins beta secretase 1 and Cathepsin S, and was run in an analogous manner to prior challenges. In Stage 1, participant ability to predict the pose and affinity of BACE1 ligands were assessed. Following the completion of Stage 1, all BACE1 co-crystal structures were released, and Stage 2 tested affinity rankings with co-crystal structures. We provide an analysis of the results and discuss insights into determined best practice methods.<br></div>

Short stature in man may result from a deficiency of GH or insulin-like growth factors (IGFs). In African pygmies and other individuals with the pygmy trait, serum GH and IGF-II are similar to levels in taller subjects, but serum IGF-I levels are low. To determine whether another population with comparably short stature has similar or related defects, we studied the Mountain Ok population of Papua New Guinea. The mean height of adult men was 152 +/- 6.0 (+/- SD) cm (n = 141), and that of women was 146 +/- 5.7 cm (n = 150). Serum GH and IGF-II concentrations were in the normal (U.S.) range in the Mountain Ok subjects. In the men, serum IGF-I values were also normal, thereby distinguishing the endocrine profile associated with short stature in these subjects from that in African pygmies. Serum IGF-I was not measured in any Mountain Ok women. Since marginal dietary protein is characteristic of the traditional Papua New Guinea diet, we determined serum albumin and prealbumin concentrations in the Mountain Ok subjects. The serum proteins were in the normal (U.S.) range (30-50 g/L for albumin; 10-40 mg/dL for prealbumin), indicating that chronic or acute malnutrition was unlikely in these subjects. Taken together, these findings indicate that short stature in the Mountain Ok people of Papua New Guinea is associated with normal serum GH, IGF-I, IGF-II, and protein levels and indicate that other factors determine stature in some populations with short stature.