Biologically adhesive delivery systems offer important advantages over conventional drug delivery systems. Here we show that engineered polymer microspheres made of biologically erodable polymers, which display strong adhesive interactions with gastrointestinal mucus and cellular linings, can traverse both the mucosal absorptive epithelium and the follicle-associated epithelium covering the lymphoid tissue of Peyer's patches. The polymers maintain contact with intestinal epithelium for extended periods of time and actually penetrate it, through and between cells. Thus, once loaded with compounds of pharmacological interest, the microspheres could be developed as delivery systems to transfer biologically active molecules to the circulation. We show that these microspheres increase the absorption of three model substances of widely different molecular size: dicumarol, insulin and plasmid DNA.

In order to achieve the required future CO 2 reduction targets significant further development of both gasoline and diesel engines is required. One of the main methods to achieve this with the gasoline engine in the short to medium term is through the application of engine downsizing, which has resulted in numerous downsized engines already being brought to production. It is, however, considered that there is still significant further CO 2 reduction potential through continued development of this technology. This paper considers the future development of gasoline engine downsizing in the short to medium term and the various technologies that can be applied to further increase the efficiency of operation. As such this paper covers, among other areas, fundamental engine layout and design, alternative boosting systems, methods of increasing part load efficiency and vehicle modelling, and uses analysis tools and engine test results to show the benefits achievable.

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