A hexafluoroisopropanol
(HFIP)-promoted hydroxydifluoromethylation
of aniline, indole, and pyrrole derivatives with difluoroacetaldehyde
ethyl hemiacetal has been developed. This protocol provides a facile
and straightforward approach to access diverse difluoromethylated
carbinols in good to excellent yields under mild conditions. Furthermore,
gram-scale and synthetic derivatization experiments have also been
demonstrated.
A multicomponent dearomative difluoroalkylation of isoquinolines has been developed with difluorinated silyl enol ethers serving as poor nucleophiles without an additional transition-metal or organic catalyst. The sequential oxidative rearomatization under different alkaline conditions provides a controllable formal C−H difluoroalkylation and difluoromethylation method for isoquinolines without peroxide or metal oxidant. A series of isoquinolines including a pharmaceutical, phenanthridine, quinolines, and difluorinated silyl enol ethers were suitable substrates to construct gem-difluorinated heterocycles. The inexpensive starting materials, mild reaction conditions, and simple operation also show practical and environmentally benign advantages.
The mixture of 2-undecyl-N-carboxymethyl-N-hydroxyethly imidazoline (UHCI) with potassium iodide (KI) as a corrosion inhibitor for carbon steel in 8% amidosulfuric acid solution was investigated by weight loss test and electrochemical methods. Results show that the combined inhibitor strongly inhibits the corrosion of 20# carbon steel in amidosulfuric acid solution, and the mixture with the mass ratio (UHCI:KI) of 9:1 has the best corrosion inhibition at a total concentration of 0.4%. The impedance spectra of carbon steel electrodes change from one time constant into two time constants when the mixture inhibitor adds into the blank solution, while the polarization curves indicate that the mixture behaves as a mixed type inhibitor. The mixture is found to follow the Langmuir adsorption isotherm, and the mechanism is chemisorption.
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