BackgroundThe Korean National Diabetes Program (KNDP) cohort study is performing an ongoing large-scale prospective multicenter investigation to discover the pathogenesis of type 2 diabetes in Korean patients. This study was performed to examine the prevalence of chronic complications in patients with type 2 diabetes among those registered in the KNDP cohort within the past 4 years.MethodsThis study was performed between June 2006 and September 2009 at 13 university hospitals and included 4,265 KNDP cohort participants. Among the participants, the crude prevalence of microvascular and macrovascular diseases of those checked for diabetes-related complications was determined, and the adjusted standard prevalence and standardization of the general population prevalence ratio (SPR) was estimated based on the 2005 Korean National Health and Nutrition Examination Survey (KNHANES) population demographics.ResultsAmong the KNDP registrants, 43.2% had hypertension, 34.8% had dyslipidemia, 10.8% had macrovascular disease, and 16.7% had microvascular disease. The SPR of the KNDP registrants was significantly higher than that of the KNHANES subjects after adjusting for demographics in the KNHANES 2005 population. However, with the exception of cardiovascular disease in females, the standardized prevalence for the most complicated items in the survey was significantly higher than that in the KNHANES subjects.ConclusionThe prevalence of macrovascular disease and peripheral vascular disease were significantly higher in Korean patients with type 2 diabetes than in the normal population. However, no significant difference was noted in the prevalence of cardiovascular disease in females.
Background : This study examined whether defects in insulin secretion contribute to the development and progression of type 2 diabetes mellitus (T2DM).Methods : Plasma insulin and glucose were measured after a glucose tolerance test to calculate the insulinogenic index (IGI) and the HOMA-IR Homeostasis model assessment of insulin resistance in subjects with normal glucose tolerance (NGT), prediabetes (preDM, n=49), and T2DM patients with disease duration <1 year (n=84), 1~5 years (n=45), or >5 years (n=37). Plasma proinsulin and adiponectin levels were also measured as a parameter of insulin secretion and resistance.Results : The mean HOMA-IR increased and the adiponectin levels decreased relative to the deterioration of glucose tolerance in NGT and preDM subjects. However, differences in the HOMA-IR were not related to disease duration in T2DM subjects. The mean IGI was similar in NGT and preDM subjects, but there were significant deteriorations in IGI relative to the duration of diabetes.Conclusions : Defects in both insulin sensitivity and insulin secretion contribute to T2DM, but decreased insulin secretion may be more important in the development and progression of T2DM.
Acute suppurative thyroiditis is an uncommon disease, which usually affects patients with pre-existing thyroid gland pathology. Here, a case of thyroid abscess associated with lymphocytic thyroiditis, was experienced in a 35-year-old female. She had a fever, chill, sore throat and tenderness in the area of the left thyroid of 10 days duration. She visited our hospital due to her persistent sore throat, which did not subside after antibiotics treatment for 5 days. On neck ultrasonography, a heterogeneous nodule (1.3×1.5×2.1 cm) in the right lobe and cyst-like nodule (1.8×1.5×2.8 cm) in the left lobe of the thyroid were found. The thyroid gland showed slightly increased, uneven uptake of Tc-99m on a thyroid scan. Pus-like fluid aspirated from the left nodule showed numerous neutrophils and necrotic materials on cytological examination. Abundant lymphocytes were found in aspirates from the right thyroid nodule. Neither a finding suggestive of pyriform sinus nor other anomaly was discovered in the neck CT scan and UGI series. After further antibiotic treatments for 2 weeks, the inflammatory symptoms and thyroid tenderness completely subsided. However, the nodule in the right lobe of the thyroid was still palpable, but without tenderness when examined after 4 weeks (J Kor Soc Endocrinol 20:385~389, 2005).
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