Prevalence of Chronic Complications in Korean Patients with Type 2 Diabetes Mellitus Based on the Korean National Diabetes Program

Abstract

BackgroundThe Korean National Diabetes Program (KNDP) cohort study is performing an ongoing large-scale prospective multicenter investigation to discover the pathogenesis of type 2 diabetes in Korean patients. This study was performed to examine the prevalence of chronic complications in patients with type 2 diabetes among those registered in the KNDP cohort within the past 4 years.MethodsThis study was performed between June 2006 and September 2009 at 13 university hospitals and included 4,265 KNDP cohort participants. Among the participants, the crude prevalence of microvascular and macrovascular diseases of those checked for diabetes-related complications was determined, and the adjusted standard prevalence and standardization of the general population prevalence ratio (SPR) was estimated based on the 2005 Korean National Health and Nutrition Examination Survey (KNHANES) population demographics.ResultsAmong the KNDP registrants, 43.2% had hypertension, 34.8% had dyslipidemia, 10.8% had macrovascular disease, and 16.7% had microvascular disease. The SPR of the KNDP registrants was significantly higher than that of the KNHANES subjects after adjusting for demographics in the KNHANES 2005 population. However, with the exception of cardiovascular disease in females, the standardized prevalence for the most complicated items in the survey was significantly higher than that in the KNHANES subjects.ConclusionThe prevalence of macrovascular disease and peripheral vascular disease were significantly higher in Korean patients with type 2 diabetes than in the normal population. However, no significant difference was noted in the prevalence of cardiovascular disease in females.

The Relationship Between Diabetic Retinopathy and Diabetic Nephropathy in a Population-Based Study in Korea (KNHANES V-2, 3)

“…The prevalence of DR has ranged between 7.0% and 38.3% in other Korean studies. [24][25][26][27] In a previous investigation in a Korean outpatient type 2 DM cohort performed in 1995, 20% of patients had microalbuminuria and 14% had overt proteinuria. 28 In 2006, 30.3% of diabetic patients were found to have microalbuminuria in a Korean nationwide survey.…”

Elevated lipoprotein(a) levels predict cardiovascular disease in type 2 diabetes mellitus: a 10-year prospective cohort study

“…In type 2 diabetes, the prevalence of CVD is 2- to 4-fold higher than in the general population [1-3]. Because of the clinical importance of CVD and the related morbidity and mortality in type 2 diabetes, predictable risk engines based on large epidemiologic studies have been suggested to identify the risk factors [4,5].…”

“…Because of the clinical importance of CVD and the related morbidity and mortality in type 2 diabetes, predictable risk engines based on large epidemiologic studies have been suggested to identify the risk factors [4,5]. Nevertheless, most of the previous studies were performed using only conventional risk factors (hypertension, lipid abnormalities, smoking, and obesity) for explaining the higher incidence of CVD in patients with type 2 diabetes [1-3]. Therefore, beyond the known modifiable risk factors, identification of another biomarker might be helpful for early detection and prediction of the future development of CVD in patients with type 2 diabetes.…”

Utilization patterns and cost of complementary and alternative medicine compared to conventional medicine in patients with type 2 diabetes mellitus

“…We performed a cross-sectional study using the database of patients with type 2 DM obtained from the KNDP, a prospective, large cohort study that began in 2005 [8].…”