[reaction: see text] The utility of Grubbs' 2nd generation metathesis catalyst has been expanded by the development of two tandem olefin metathesis/oxidation protocols. These ruthenium-catalyzed processes provide cis-diols or alpha-hydroxy ketones from simple olefinic starting materials.
A Facile Synthesis of 2-Acyl and 2-Alkylaminobenzimidazoles for 5-Lipoxygenase Inhibitors. -A variety of substituted 2-aminobenzimidazoles is prepared from o-phenylenediamines and tested as 5-lipoxygenase inhibitors. Several acylaminobenzimidazoles such as (IIIa)-(IIIf) show good leukotriene inhibition activity. -(LEE, J. H.; AN, M. H.; CHOI, E. H.; CHOO, H.-Y. P.; HAN*, G.; Heterocycles 70 (2006) 1, 571-580; Dep. Biotechnol., Coll. Eng., Yonsei Univ., Seoul 120-749, S. Korea; Eng.) -R. Staver 23-117
Hoch funktionalisierte gespannte Ringe entstehen bei den Cycloadditionen von Cyclobutadien mit Alkinen. Eine intramolekulare [2+2+1]‐Cycloaddition wurde für ein Spektrum von (Cyclobutadien)tricarbonyleisen‐Substraten mit angebundenen Alkinyl‐Einheiten optimiert (siehe Schema; CAN=Cer(IV)‐ammonium‐nitrat). Die Brücke zwischen den reagierenden funktionellen Gruppen hat einen starken Einfluss auf das Ergebnis der Transformationen.
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