A Facile Synthesis of 2-Acyl and 2-Alkylaminobenzimidazoles for 5-Lipoxygenase Inhibitors

Further and new target-based benzimidazole anthelmintics active against Teladorsagia circumcincta

“…Type II compounds have been reported as potential inhibitors of 12-lipoxygenase [11] , and 5-lipoxygenase [ 12 ], as well as anti-Helicobacter pylori agents [ 13 ], anticancer [ 14 ], or as antiproliferative [ 15 ]. With respect to compounds types III and IV, descriptions on activities such as fungicidal [16][17][18][19][20] , antimalarial, anti-Trypanosoma brucei [ 21 ], anthelmintic [ 22 ], against HIV-1 proteases, or hepatitis B virus [ 23 ], neuroprotective agents targeting mGluR5 [ 24 ], inhibitors of interleukin-1-receptor-associated kinase-4 [25] antiproliferative [ 26 ], or inhibitors of 5-lipoxygenase [ 12 ] can be found.…”