Background-TD-5108 is a potent, selective high intrinsic activity serotonin 5-HT 4 receptor agonist.

Objectives Abnormal gastric accommodation to a meal results in dyspepsia. Current methods to measure gastric volume (GV) are invasive or involve ionizing radiation. The aims of this study were: 1. To compare fasting and postprandial (PP) GVs measured by 99mTc-SPECT and 3-dimensional ultrasound (3D-US) in adults; 2. To assess the performance characteristics of 3D-US measurement of GV during fasting and postprandially; 3. To develop normative data of GVs in 24 healthy adolescents. Methods Eleven adults underwent SPECT and 3D-US simultaneously to measure GV, and a second 3D-US alone within a week of the first study. Twenty-four adolescents underwent one 3D-US measurement. Each study included fasting, 300 mL Ensure® meal, and 0-30 min PP GV measurements. Results 3D-US identifies GV accommodation to 300 mL Ensure®. Delta (0-30 min average PP-fasting) GV was 444 mL (median, IQR 422, 534) for 3D-US and 543 mL (median, IQR 486, 564) for SPECT, (p=0.15). There were larger interindividual coefficients of variation (COVs) for GV by 3D-US (60.3% fasting and 21.3% average PP) compared to 19% fasting and 9.2% PP for SPECT. Intraindividual COV for the two 3D-US measurements in adults were 84% fasting and 44% average PP. The estimated GVs for the adolescent group (median, 25th-75th IQR) were 33 (18-53mL) fasting, 330 (284-357mL) 30 min PP, and 281 (240-324mL) for delta GV. Conclusion 3D-US is a promising method to measure GV accommodation to a meal. Large COVs reflect the learning stage in development of this promising technique.

We found oral pyridostigmine to be helpful in children with different GI motility problems. Pyridostigmine should be considered in such patients when other treatment interventions have not been beneficial.

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