How does one choose the appropriate pharmacotherapy for pediatric patients with functional dyspepsia?

Gastric accommodation: Physiology, diagnostic modalities, clinical relevance, and therapies

“…The use of high-resolution manometry catheters has been validated in adults and has shown a correlation between an increase in intragastric pressure and increase in satiety scores. 49,53 Drawbacks include catheter displacement and inability to measure the volume size of the stomach. 50 The catheter should be placed in the proximal stomach, as opposed to the distal stomach, to prevent dumping-like symptoms.…”

“…49 Nonetheless, this technique proved to be feasible in children, as it is less invasive than the barostat and radiation-free. 53 Further validation studies are needed.…”

“…Cyproheptadine is an antagonist of serotonin, histamine H 1 , and muscarinic receptors that is commonly used in children with functional dyspepsia. 53 Although not proven, its effects are attributed to increasing fundic relaxation and appetite stimulation. 53 Given that the primary symptoms in patients with IFA are early satiety and weight loss, this drug seems to be useful for this population.…”

“…53 Although not proven, its effects are attributed to increasing fundic relaxation and appetite stimulation. 53 Given that the primary symptoms in patients with IFA are early satiety and weight loss, this drug seems to be useful for this population. In fact, a systematic review showed that cyproheptadine helps facilitate weight gain in underweight patients.…”

Prevalencia de dispepsia funcional en adolescentes cubanos

“…La dispepsia funcional (DF) es un trastorno frecuente en la infancia, se refiere a síntomas gastrointestinales superiores que incluyen dolor epigástrico o sensación de ardor, saciedad temprana y plenitud posprandial, y que no están relacionados con las deposiciones ni con otra etiología para explicar estos síntomas. Esta puede causar un deterioro significativo en la calidad de vida (1,2) .…”