Results Group A did not differ from control group. Group B had higher titers of anti-ABCA1 antibodies (p=0.004), with 4 patients showing positive anti-ABCA1 titers (11.4%). In group B, anti-ABCA1 antibodies titers tend to negatively correlate with HDL (p=0.06) and apoliporoteinA-I levels (p=0.04). In both groups, anti-HDL antibodies did not correlate with anti-ABCA1 titers. Conclusions This is the first report of naturally occurring antibodies against ABCA1. These antibodies are increased in patients with SLE with at least 4 SLICC classification criteria. Future studies will determine their pathogenic role.

Background and aimsTo describe organ involvement, disease activity patterns, and damage characteristics in a cohort of Filipino patients with systemic lupus erythematosus (SLE), observed over 3 years.MethodsConsenting SLE patients at University of Santo Tomas (UST) Hospital with minimum 3 visits/year were assessed over 3 years until July 2016. Disease activity patterns included clinically quiescent disease (CQD; SLEDAI=0 in 3 visits); minimal persistent disease (MDA; SLEDAI=1 in >1 visit); relapsing remitting disease (RRD; SLEDAI ≥2 in 1 of 3 visits); chronic active disease (CAD; SLEDAI ≥2 in at least 2 of 3 visits). SLICC Damage Index (SDI) characteristics were correlated with steroid use.Results127 SLE patients (117, 92% females), mean 28.81+10.14 SD (range 4–57) age at diagnosis, mean 7.94+5.61 SD (range 1–25) years disease duration. Organ involvement included mucocutaneous (121,95%), musculoskeletal (113, 89%) and renal (87, 68.5%). At 1 year there were 48 (40.7%) patients with CAD, 37 (31.4%) CQD, 30 (25.4%) RRD, 3 (2.5%) MDA. At 3 years, CAD patients totaled 23 (19.5%), CQD 59 (50%). Table 1 Mean cumulative prednisone dose was 21.42+17.63 at initial damage involvement. Cataract was most common SDI (26, 20.5%), significantly correlated with cumulative steroid, p<0.01. There were 131 flares in 87 patients, including 73 (56%) renal flares. Eleven patients died during the 3 year observation period.Abstract 435 Table 1Evolution of disease activity patterns from 1 to 3 years.ConclusionsThis study reflects improvement in disease patterns among patients participating in an observational cohort study. Damage is largely driven by high cumulative steroid use.

Background and aims The prevalence of ANA-negative SLE is reportedly 5%-20%. Cytoplasmic or mitotic cell indirect immunofluorescence (IIF) patterns are usually reported as ANA-negative. This study examined the prevalence of ANAnegativity (no intracellular IIF pattern) and pure cytoplasmic and/or mitotic IIF patterns (CMP) in the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort and examined demographic, clinical and autoantibody associations. Methods Three groups were examined 1) ANA-positive (presence of nuclear IIF pattern), 2) ANA-negative (no IIF pattern), and 3) pure CMP. ANA were detected by IIF on HEp-2000 substrate, SLE-related autoantibodies by laser bead immunoassay, and anti-dsDNA and anti-dense fine speckles 70 (DFS70) by chemiluminescence immunoassay. Results 1137 patients were included; 89.9% were female. 92.3% were ANA-positive, 6.2% were ANA-negative, and 1.5% had a CMP. In the multivariate analysis (Tables 1 and 2)