435 Disease activity patterns among filipino patients with systemic lupus erythematosus: a 3-year observational study

Abstract

Background and aimsTo describe organ involvement, disease activity patterns, and damage characteristics in a cohort of Filipino patients with systemic lupus erythematosus (SLE), observed over 3 years.MethodsConsenting SLE patients at University of Santo Tomas (UST) Hospital with minimum 3 visits/year were assessed over 3 years until July 2016. Disease activity patterns included clinically quiescent disease (CQD; SLEDAI=0 in 3 visits); minimal persistent disease (MDA; SLEDAI=1 in >1 visit); relapsing remitting disease (RRD; SLEDAI ≥2 in 1 of 3 visits); chronic active disease (CAD; SLEDAI ≥2 in at least 2 of 3 visits). SLICC Damage Index (SDI) characteristics were correlated with steroid use.Results127 SLE patients (117, 92% females), mean 28.81+10.14 SD (range 4–57) age at diagnosis, mean 7.94+5.61 SD (range 1–25) years disease duration. Organ involvement included mucocutaneous (121,95%), musculoskeletal (113, 89%) and renal (87, 68.5%). At 1 year there were 48 (40.7%) patients with CAD, 37 (31.4%) CQD, 30 (25.4%) RRD, 3 (2.5%) MDA. At 3 years, CAD patients totaled 23 (19.5%), CQD 59 (50%). Table 1 Mean cumulative prednisone dose was 21.42+17.63 at initial damage involvement. Cataract was most common SDI (26, 20.5%), significantly correlated with cumulative steroid, p<0.01. There were 131 flares in 87 patients, including 73 (56%) renal flares. Eleven patients died during the 3 year observation period.Abstract 435 Table 1Evolution of disease activity patterns from 1 to 3 years.ConclusionsThis study reflects improvement in disease patterns among patients participating in an observational cohort study. Damage is largely driven by high cumulative steroid use.