Nanotechnology empowered localized cancer chemotherapy has indicated a promising performance for targeting and controlled release of anticancer agents over a period of time to eliminate local-regional recurrence of cancers and also to improve the tissue regeneration during/after treatment. Electrospun nanofiber-based implantable drug-delivery systems have been established as one of the most effective approaches for localized cancer treatment, allowing the on-site delivery of anticancer agents and reducing systemic toxicities and side effects to normal cells. The present review aimed to summarize the latest cutting-edge research on applications of electrospun-based systems for local chemotherapy. Meantime, in vitro and in vivo studies conducted using various anticancer agents along with the capability of electrospun nanofibers for combinatorial/synergistic chemotherapy as well as existing challenges and the potential dramatic advances in applying this pioneering approach for clinical transition in localized treatments of cancer is also discussed. K E Y W O R D S chemotherapy, drug delivery, electrospun nanofiber Recent advances in electrospun nanofiber-mediated drug delivery strategies for localized cancer chemotherapy.
Common thyme with scientific name Thymus vulgaris is one of the Iran indigenous plants that exist widely in southern and central regions of country. This plant has medical applications in traditional medicine including antibacterial and antifungal activity affecting gastrointestinal and chronic diseases. All Thymuses are rich in terms of volatile compounds and mainly consist of thymol and Carvacrol that are considered as strong disinfectants. With regard to valuable properties of common thyme, we decided to investigate effects of Zataria multiflora bosis alcoholic extract on some components of Complement system (c 1 inhibitor, CH50, C 3 , C 4) and serum IgM in rat. In this research two treatment groups were fed with Zataria multiflora bosis alcoholic extract at dose of 200 and 400 mg/kg for 30 days and the third group as whiteness did not received no compound. In this study after measuring components of complement system and IgM, CH50 amount in two treatment groups showed a significant increase than the control group (p<0.05). Amount of C 1 inhibitor also showed a significant increase in the group 1 than the control group (p<0.05). Also amount of IgM in two treatment groups showed a relative increase than the control group.
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