connective tissue and omentum, and not serosal or endothelial cells, as usually stated. Following the injection of a fatal dose of the streptococcus in the pleura of a normal rabbit, the polymorphononuclear leukocytes rise from a negligible percentage to more than 90 in twentyfour hours, the clasmatocytes fall from an average of 85 per cent, to 15 per cent., the bacteria steadily increase, invasion of the pericardium and other pleura follows and the animal dies in from three to seven days. In an actively immunized animal, the clasmatocyte count remains high, and at twenty-four hours (the critical phase) averages 74 per cent. At this time, the bacteria have decreased markedly in number or, in the majority of instances, the cavity has become sterile. In a similar manner, other conditions of successful resistance to streptococcus pleurisy are constantly associated with a peristently high clasmatocyte count; the use of a sublethal dose of bacteria, and preparation of the cavity by plain broth or by streptococcus immune serum. Other conditions of lack of protection, preparation by normal rabbit serum and the use of filtrates of pleural exudates from fatally infected animals (aggressins?), are all followed by a drop in the clasmatocytes and a rise in the polymorphonuclear cells.
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