Vitiligo is considered the most common disorder of pigmentation. Its prevalence ranges between 0.1% and 2% worldwide. The pathogenesis is mainly as a result of affection of the skin melanocytes. Factors as age, race, sex, ethnicity, or skin color do not relate to the incidence of this disease. 1 Vitiligo is categorized as autoimmune, and this is currently the most widely accepted hypothesis. However,

Polymorphisms of ApaI and TaqI may have a role in the pathogenesis of AV as A allele and AATT combined genotype could be considered protective against acne development and tt genotype and t allele may increase the risk of AV development. VitD deficiency can be considered as a risk factor for AV development.