Vitamin D receptor (VDR) gene polymorphism in Egyptian vitiligo patients

Saudi, Wael M.; Swelam, Mervat M.; El-Barbary, Rasha A. H.; Zakaria, Lola; Gaber, Dalia A

doi:10.1111/jocd.13606

Cited by 7 publications

(8 citation statements)

References 21 publications

(31 reference statements)

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“…In our study, we found that the female sex (57.5%) was more affected than males (42.5%). This is in accordance with the finding of Martins et al (16) and Saudi et al (13) who found that the incidence of vitiligo was higher among female sex. This may be attributed to the fact that females are more concerned by the disease and its distressing appearance more than males, leading to an increased and earlier presentation of females to dermatology clinics.…”

Section: Discussionsupporting

confidence: 93%

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Effect of Narrow Band –UVB Phototherapy on Circulating T-Regulatory cells and Serum IL-17 Level in Egyptian Patients with Non-Segmental Vitiligo

Ghanem¹,

Mitwally²,

State³

et al. 2021

The Egyptian Journal of Hospital Medicine

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Background: Vitiligo is an acquired chronic depigmenting disorder of the skin, characterized by the development of milky white macules and patches resulting from a selective loss of epidermal melanocytes. There are various theories about its pathogenesis and the etiology is multifactorial associating genetic and environmental factors together with metabolic and immune alterations. Objective: To demonstrate the role of circulating T regulatory cells (Treg) (specifically CD4 + , CD4 + 25 + , CD4 + 25 + FoxP3) and serum level of IL-17 in pathogenesis of non-segmental vitiligo (NSV) in Egyptian patients. Patients and methods: This case-control study was carried out on eighty subjects in the period from January 2018 to March 2020, attending Dermatology, Andrology & STDs Outpatient Clinic of Mansoura University Hospital. Subjects were classified into two groups: Group (1): patients group included forty patients suffering from NSV (vitiligo patients group). Group (2): control group included forty persons who were selected from hospital workers with no personal or family history of vitiligo or systemic autoimmune diseases in their first-degree relatives. Results: After NBU-VB treatment, there was a highly statistically significant increase in CD4 + %, CD4 + 25 + % and CD4 + 25 + FoxP3% expression with a mean of 12.1 ± 4 versus 10 ± 3.2, 3.5 ± 1.1 versus 3.2 ± 1 and 1.8 ± 0.6 versus 1.1 ± 0.3 when compared to before treatment levels respectively. Also, a highly statistically significant decrease in IL-17 level with the mean of 14.3 ± 4.1 versus 19.9 ± 6 pg/mL when compared to before treatment levels. There was a highly statistically significant positive correlation between CD4 + 25 + % expression and CD4 + % expression in vitiligo group before and after treatment. Conclusion: Lower CD4 + %, CD4 + 25+% and CD4 + 25 + FoxP3% expression and elevated serum levels of IL-17 positively were correlated with disease severity.

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Section: Discussionsupporting

confidence: 93%

“…The mean age of the case group was 30.8 years, and 28.11 years in Nejad et al (11) and Amer et al (12) studies respectively. However, in Saudi et al (13) study, mean age of patients was 43.53 ± 14.35 years. These data reinforced that vitiligo is a disease that occurs at any age.…”

Section: Discussionmentioning

confidence: 89%

Effect of Narrow Band –UVB Phototherapy on Circulating T-Regulatory cells and Serum IL-17 Level in Egyptian Patients with Non-Segmental Vitiligo

Ghanem¹,

Mitwally²,

State³

et al. 2021

The Egyptian Journal of Hospital Medicine

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“…The varied characteristics of the population are also important factors that alter the production of vitamin D at the skin level, among them are age, due to the deterioration of the skin over time, so that older adults have thinner skin, which reduces the ability to synthesize vitamin D, also influences the way of dressing, the place of work, quality of life and the different measures used over the years to limit sun exposure generally have a great impact on the synthesis of vitamin D [6].…”

Section: Table 1 Vitamin D Requirement Per Daymentioning

confidence: 99%

Serum Vitamin D concentrations and their association with the clinical severity of vitiligo

Baez¹,

Mangones²,

Lozano³

et al. 2022

World J. Adv. Res. Rev.

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Vitiligo is the most common acquired depigmentation of the skin, affecting the patient's self- image and negatively affecting quality of life. As for the pathogenesis of vitiligo, there is an autoimmune theory. Vitamin D deficiency has been shown to exist in many autoimmune diseases. Vitamin D is an essential hormone with pleiotropic effects, especially anti-apoptosis and regulatory functions of melanocyte proliferation and differentiation. It has been hypothesized that it may play a supportive role in the repigmentation of white matter lesions. The immunomodulatory activity of vitamin D may be used to treat vitiligo.

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“…Two of the 15 studies were eliminated because they lacked VDR polymorphism data or because they were reviews. The meta-analysis included 13 trials with 2034 cases and 2771 controls [11][12][13][14][15][16][17][18][19][20][21][22][23] (Table 1; Figure 1). Eleven studies examined the VDR ApaI polymorphism, 12 examined the VDR TaqI polymorphism, seven looked at the BsmI polymorphism, and eight looked at the VDR FokI polymorphism (Table 1).…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

“…Some studies have established a correlation between the VDR polymorphisms and vitiligo susceptibility, whereas others have found no correlation. [11][12][13][14][15][16][17][18][19][20][21][22][23] These disparities are likely due to the small sample sizes, low statistical power, and/or clinical heterogeneity. To overcome the limitations of individual studies, resolve discrepancies, and reduce the likelihood of random errors being responsible for false-positive or falsenegative associations, [24][25][26] we conducted an updated meta-analysis to identify whether VDR ApaI, TaqI, BsmI, and TaqI polymorphisms are correlated to vitiligo susceptibility.…”

Section: Introductionmentioning

confidence: 99%

Association between vitamin D receptor polymorphisms and vitiligo susceptibility: An updated meta‐analysis

Lee

Song

2022

J of Cosmetic Dermatology

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Background Vitamin D receptor (VDR) polymorphisms may play an important role in the vitiligo susceptibility. There have been many studies looking at the associations between VDR polymorphisms and vitiligo risk, but the conclusions are still up for debate. Aim This study aimed to determine whether polymorphisms in the VDR are associated to the susceptibility to vitiligo. Methods Vitamin D receptor polymorphisms in vitiligo patients and controls were identified using PubMed/Medline and Embase databases. The relationships between the VDR ApaI, TaqI, BsmI, and TaqI polymorphisms and vitiligo were investigated using meta‐analyses of all participants and Asian, Arab, European, and Latin American groups. Results This meta‐analysis included 13 papers with 2034 patients and 2771 controls. In all individuals, there was no link between vitiligo and the VDR ApaI A allele (OR = 0.889, 95% CI = 0.713–1.109, p = 0.298). However, in Asians (OR = 0.721, 95% CI = 0.553–0.940, p = 0.016) but not in Europeans or Arabs, there was a link between the VDR ApaI A allele and vitiligo. Utilizing recessive, dominant, and homozygote contrast models, a link between vitiligo and the VDR ApaI polymorphism was discovered in Asians. Meta‐analysis of the VDR BsmI polymorphism showed a significant association between vitiligo and the B allele (OR = 0.812, 95% CI = 0.686–0.961, p = 0.015). In contrast, no connection between vitiligo and VDR polymorphisms was identified for TaqI and FokI polymorphisms. Conclusion In the Asian population, ApaI and BsmI polymorphisms in VDR have been correlated to vitiligo susceptibility. However, TaqI and FokI polymorphisms in VDR are not associated with vitiligo susceptibility in European, Asian, Arab, and Latin American populations.

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Vitamin D receptor (VDR) gene polymorphism in Egyptian vitiligo patients

Cited by 7 publications

References 21 publications

Effect of Narrow Band –UVB Phototherapy on Circulating T-Regulatory cells and Serum IL-17 Level in Egyptian Patients with Non-Segmental Vitiligo

Effect of Narrow Band –UVB Phototherapy on Circulating T-Regulatory cells and Serum IL-17 Level in Egyptian Patients with Non-Segmental Vitiligo

Serum Vitamin D concentrations and their association with the clinical severity of vitiligo

Association between vitamin D receptor polymorphisms and vitiligo susceptibility: An updated meta‐analysis

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