Among benthic animals, soft-bodied, sessile animals have concentrated most of the interest in pharmaceutical studies. The toxic chemicals are crucial for invertebrates lacking morphological defence structures such as shells or spines (De Rosa, 2002; Blunt et al., 2008). Indeed, sponges are the most prolific marine producers of novel compounds in terms of new metabolites reported annually (Taylor et al., 2007; Menna, 2009). Furthermore, more sponge-derived compounds are in clinical and preclinical trials (e.g., as anticancer or anti-inflammatory agents) than compounds from any other marine taxa (Taylor et al., 2007; Menna, 2009). A wide variety of novel secondary bioactive metabolites have been isolated from various species of marine sponges worldwide , including powerful antiviral, antimalarial, antitumour and anti-inflammatory, as well as antimicrobial (antibiotic) compounds (Faulkner, 2002). Marine-based microorganisms are also a potential source of new medicines. However, the successes to date are based upon a very limited investigation of these microorganisms in few areas of the world oceans (Pushparaj et al., 1998), suggesting a high potential for continued discovery of new drugs from these microbes (Board, 2002). Accumulated evidence also suggests that microorganisms living in the body of sponges could well be the true source of at least some of these metabolites found in Mediterranean sponges (Thiel et Imhoff, 2003) and in other species from other oceans (Anand et al., 2006; Taylor et al., 2007). Marine sponges often contain diverse and abundant microbial communities, including bacteria, microalgae, and fungi. In some cases, these microbial associates comprise as much as 40% of the sponge volume and can contribute significantly to host metabolism via e.g. photosynthesis or nitrogen fixation (Taylor et al., 2007). Many antimicrobial, antifouling substances have been found among these kinds of bacteria due to the specialized role they play in their respective hosts (Burgess et al., 1999; Holmstrom et al., 2002). It is suggested that the primary role of these antibiotic substances could be related to ecological competition (Zheng et al., 2005). In the present work, we have studied antibacterial activity of isolated marine bacteria associated with same invertebrates belonging to the Moroccan Atlantic coast. Material and Methods:-Biological materials:-The marine sponges (Haliclona viscosa, Cliona viridis, Ircinia spinulosa and Paraleucilla magna) and the sea concomber were collected from the littoral Atlantic of El-Jadida (Morocco) at a depth ranging from 3 to 10 m. After sampling, the samples were cleaned, photographed, washed with sea water and immediately transported to the laboratory. The sponges Haliclona viscosa, Cliona viridis and Ircinia spinulosa were identified by Dr. Maria-Jesús Uriz, Research Professor at the Centro de Estudios Avanzados (El Amraoui et al., 2010), while the sponge Paraleucilla magna was identified by Dr.
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