The concentration levels of 11 perfluorinated carboxylic (PFCA) and eight sulfonic (PFSA) acids were determined in the serum of 13 professional ski waxers. The same components were also determined in workroom aerosols and in fluoro containing solid ski waxes and ski wax powders. The highest median concentration (50 ng/mL) was detected for perfluorooctanoic acid (PFOA), which is around 25 times higher than the background level. For the first time perfluorotetradecanoic acid (PFTeDA) has been found in human serum. Positive statistically significant associations between years exposed as ski waxer and seven different PFCAs were observed. The serum concentrations of the PFCAs with carbon chain lengths from C(8) to C(11) were reduced by around five to 20% on average during the eight month exposure free interval, whereas the reduction was substantially larger when the carbon chain lengths were smaller than C(8) or larger than C(11). This study links for the first time PFCAs in the ski waxers serum to exposure from the work room aerosols. Not only professional ski waxers but also the significant larger group of amateur skiers and waxers are potentially exposed to these compounds.
The dialdehyde glyoxal (ethanedial) is an increasingly used industrial chemical with potential occupational health risks. This study describes the development of a personal sampling methodology for the determination of glyoxal in workroom air. Among the compounds evaluated as derivatizing agents; N-methyl-4-hydrazino-7-nitrobenzofurazan (MNBDH), 1,2-phenylenediamine (OPDA), 1-dimethylaminonaphthalene-5-sulfonylhydrazine (dansylhydrazine, DNSH) and 2,4-dinitrophenylhydrazine (DNPH), DNPH was the only reagent that was suitable. Several different samplers were evaluated for sampling efficiency of glyoxal in workroom air using DNPH as derivatizing agent; in-house DNPH coated silica particles packed in two different types of glass tubes, impingers containing acidified DNPH solution, filter cassettes containing glass fibre filters coated with DNPH, a commercially available solid phase cartridge sampler originally developed for formaldehyde sampling (Waters Sep-Pak DNPH-silica cartridge), and the commercially available SKC UMEx 100 passive sampler originally developed for formaldehyde sampling. Aldehyde atmospheres for sampler evaluation were generated with an in-house made vapour atmosphere generator coupled to a sampling unit, with the possibility of parallel sampling. The resulting glyoxal-DNPH derivative was determined using both LC-UV and LC-APCI-MS with negative ionization. By far, the highest recovery of glyoxal was obtained employing one of the in-house DNPH coated silica samplers (93%, RSD = 3.6%, n = 12).
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