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Psoriasis increases the risk of cardiovascular disease (CVD). Biomarkers for cardiovascular (CV) risk stratification in psoriasis are lacking, and the effects of psoriasis biologics on CV risk reduction remain unclear. The goal of this study was to identify biomarkers of CV risk in psoriasis blood that are reduced by ustekinumab. We quantified 276 inflammatory and CV‐related serum proteins with Olink's multiplex assay in 10 psoriasis patients (vs. 18 healthy controls) and after 12 weeks of ustekinumab treatment. For each protein down‐regulated after treatment, the literature was reviewed for studies assessing the protein's association with CVD. Data were collected from each study to calculate CV risk thresholds for each protein, which were compared with protein levels in psoriasis patients before and after treatment. Our results showed that 43 out of 276 proteins were down‐regulated after treatment, 25 of which were initially up‐regulated at baseline (vs. controls, all p‐values ≤0.1). 8 down‐regulated proteins were initially elevated above thresholds associated with enhanced CV risk in the literature (myeloperoxidase, C‐X‐C motif chemokine 10, E‐selectin, interleukin‐6, cystatin B, von Willebrand factor, tumor necrosis factor receptor 1 and N‐terminal prohormone brain natriuretic peptide). Treatment lowered these proteins to below their risk thresholds, except for IL‐6, which was lowered but remained at its risk threshold despite successful psoriasis skin treatment. In summary, 12 weeks of ustekinumab treatment reduced serum proteins present at levels associated with CV risk in psoriasis patients. Further studies can evaluate these proteins as potential ustekinumab‐modulated biomarkers of CV risk in psoriasis and the impact of ustekinumab on CV risk reduction.

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Introduction: Over the past decade, our understanding of psoriatic arthritis (PsA) as a chronic inflammatory condition with a heterogenous manifestation has vastly improved. A better understanding of pathophysiology, susceptibility, clinical features, and treatment have all warranted a comprehensive and organized review of this musculoskeletal disorder which continues to affect a growing population of the western world along with psoriasis patients.Methods: Relevant articles on PsA were retrieved through a selective search on PubMed.Discussion: By acknowledging the present state of diagnostic methods and subsequent treatment strategies, clinicians will be more equipped to identify and treat this condition while also encouraging the importance of screening those who may be susceptible based on immune, environmental, and genetic factors. This article reviews the current knowledge of PsA and addresses the areas for future research.