Pediatric COVID toes and fingers

Koschitzky, Merav; Oyola, Ryan Rivera; Lee-Wong, Mary; Abittan, Brian J.; Silverberg, Nanette B.

doi:10.1016/j.clindermatol.2020.12.016

Cited by 20 publications

(19 citation statements)

References 26 publications

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“…Many observational reports have offered circumstantial evidence pointing toward an association with SARS-CoV-2 infection, although the immunological and PCR data have been more limited, with only the minority of cases having evidence of infection ( 1 , 4 – 8 ) and some studies having none whatsoever ( 2 , 3 , 12 ). Importantly, PC cases are being diagnosed and managed differently than idiopathic chilblains due to this presumed relationship with SARS-CoV-2 ( 19 ). In this study, we provide compelling evidence of prior SARS-CoV-2 infection in our cohort with a temporal association in local infection rate ( Fig.…”

Section: Discussionmentioning

confidence: 99%

“…This hypothesized relationship between innate type I interferon responses potentially driving PC does merit further discussion. PC has been described as a “late” finding in response to COVID-19, occurring typically after symptom onset in a range from 1 to 4 wk ( 1 , 4 , 19 ). In mild cases of SARS-CoV-2 infection in younger, healthier patients—the described population primarily affected by PC—both viral load and type I interferon responses peak in the first week and decline thereafter ( 30 , 31 ).…”

Section: Discussionmentioning

confidence: 99%

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Lack of association between pandemic chilblains and SARS-CoV-2 infection

Gehlhausen

Little

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

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An increased incidence of chilblains has been observed during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and attributed to viral infection. Direct evidence of this relationship has been limited, however, as most cases do not have molecular evidence of prior SARS-CoV-2 infection with PCR or antibodies. We enrolled a cohort of 23 patients who were diagnosed and managed as having SARS-CoV-2–associated skin eruptions (including 21 pandemic chilblains [PC]) during the first wave of the pandemic in Connecticut. Antibody responses were determined through endpoint titration enzyme-linked immunosorbent assay and serum epitope repertoire analysis. T cell responses to SARS-CoV-2 were assessed by T cell receptor sequencing and in vitro SARS-CoV-2 antigen-specific peptide stimulation assays. Immunohistochemical and PCR studies of PC biopsies and tissue microarrays for evidence of SARS-CoV-2 were performed. Among patients diagnosed and managed as “covid toes” during the pandemic, we find a percentage of prior SARS-CoV-2 infection (9.5%) that approximates background seroprevalence (8.5%) at the time. Immunohistochemistry studies suggest that SARS-CoV-2 staining in PC biopsies may not be from SARS-CoV-2. Our results do not support SARS-CoV-2 as the causative agent of pandemic chilblains; however, our study does not exclude the possibility of SARS-CoV-2 seronegative abortive infections.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lack of association between pandemic chilblains and SARS-CoV-2 infection

Gehlhausen

Little

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

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“… COVID-19: symptoms. Elaborated on the basis of available literature data [ 19 , 20 , 21 , 22 ]. ARDS: acute respiratory distress syndrome; RF: respiratory failure; SS: severe symptoms; CIS: critical illness symptoms; MODS: multiple organ dysfunction syndrome.…”

Section: Figurementioning

confidence: 99%

Elements and COVID-19: A Comprehensive Overview of Studies on Their Blood/Urinary Levels and Supplementation with an Update on Clinical Trials

Ścibior

Wnuk

2022

Biology

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The current report provides a brief overview of the clinical features, hematological/biochemical abnormalities, biomarkers, and AI-related strategies in COVID-19; presents in a nutshell the pharmacological and non-pharmacological therapeutic options; and concisely summarizes the most important aspects related to sociodemographic and behavioral factors as well as comorbidities having an impact on this disease. It also gives a brief outline of the effect of selected elements on immune response and collects data on the levels of micro-/macro-elements and toxic metals in the blood/urine of SARS-CoV-2 infected patients and on supplementation with minerals in COVID-19 subjects. Moreover, this review provides an overview of clinical trials based on the use of minerals alone or in combination with other agents that can provide effective responses toward SARS-CoV-2 infection. The knowledge compiled in this report lays the groundwork for new therapeutic treatments and further research on biomarkers that should be as informative as possible about the patient’s condition and can provide more reliable information on COVID-19 course and prognosis. The collected results point to the need for clarification of the importance of mineral supplementation in COVID-19 and the relationships of the levels of some minerals with clinical improvement.

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“…In addition, ears and cheeks can also be involved as in classical perniosis but the terms COVID ears or COVID cheeks/face has not been proposed for the same. [ 6 ]…”

Section: Introductionmentioning

confidence: 99%

”COVID” Terminology in Dermatology

Gaurav¹,

Grover²

2021

Indian Journal of Dermatology

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Ever since the beginning of COVID-19 pandemic, mucocutaneous manifestations started being noticed and are still being documented. Many of these have been described with the prefix “COVID” and may occur due to the infection (e.g., COVID rash), use of personal protective equipment in healthcare workers (e.g., COVID hand dermatitis) or extensive use of novel vaccines (e.g., COVID arm). This article attempts to summarize such entities with clinical relevance to dermatologists and physicians in general and to create awareness about this fast-evolving COVID lexicon.

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Pediatric COVID toes and fingers

Cited by 20 publications

References 26 publications

Lack of association between pandemic chilblains and SARS-CoV-2 infection

Lack of association between pandemic chilblains and SARS-CoV-2 infection

Elements and COVID-19: A Comprehensive Overview of Studies on Their Blood/Urinary Levels and Supplementation with an Update on Clinical Trials

”COVID” Terminology in Dermatology

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