Electronic contact lenses are used for noninvasively monitoring vital human signs and medical parameters. However, maintaining a secure communications connection and a self‐sustainable power source are still looming challenges. Herein, a proof‐of‐concept electronic contact lens is demonstrated that includes a spiral antenna with its wireless circuit unit for data telemetry, a rectifier circuit for power conditioning, and a micro‐light‐emitting diode (μLED) as a load. The spiral antenna with its rectifying circuit is designed considering operation in the industrial, scientific, and medical (ISM) band of 2.4 GHz. The spiral coil with an inner diameter of 10 mm, an outer diameter of 12 mm, and a wire width of 0.2 mm is fabricated on a donut‐shaped flexible polyimide substrate. For biocompatibility purposes, polyimide is used as the contact lens substrate and polydimethylsiloxane (PDMS) is used for encapsulation. A 3D‐printed eye model is developed for accurately shaping the curvature of the PDMS‐encapsulated contact lens. The reflection coefficient (S11) of the fabricated antenna is tested in different conditions and on an eye model to mimic the liquid condition of the human eye. In a wide range of conditions, a minimum of −20 dB reflection coefficient (S11) is obtained.
The human eye contains multiple biomarkers related to various diseases, making electronic contact lens an ideal non-invasive platform for their diagnosis and treatment. Recent advances in technology have enabled the monitoring and diagnosis of glaucoma from Intraocular Pressure (IOP) detection, diabetes from glucose concentration detections, and other biosensors for pH and temperature sensing. Different sensor designs have led to distinct power transfer techniques, among which inductively coupled power transfer is considered most favourable for electronic contact lenses power delivery applications. Therefore, loop antenna, spiral shape antenna, and antenna with nanomaterials such as graphene and hybrid silver nanofibers have been explored under Industrial, Scientific, and Medical (ISM) frequency bands for both Wireless Power Transfer (WPT) and data communication. Notably, spiral antennas are also considered as the component of IOP sensing using capacitive sensors to detect the changes in frequency caused by pressure. This article reviews the stateof-the-art technologies in electronic contact lens sensors and their power delivery techniques. Herein, diverse sensing methods, materials, and power transfer techniques and the promising future trends and challenges in electronic contact lenses have been presented.
Background: Oral microbiota reported to be associated with pancreatic diseases, including pancreatic cancer. However, the association of oral microbiome and pancreatic cancer has not been reviewed systematically. Objectives: To systematically investigate the association between the oral microbiome and pancreatic cancer risk. Design: A systematic review and meta-analysis. Data Sources and Methods: Systemic searches were conducted using PubMed, Medline, Cochrane Library, and Embase databases without any language restriction from conception to August 29, 2020. The studies that evaluated the association of oral microbiome and pancreatic cancer risk were included in this meta-analysis. Results: The six included studies encompassed a total of 863 pancreatic cancer cases and 906 controls. Four studies reported the overall oral microbiome in pancreatic cancer cases. A total of 12–17 species/clusters were correlated with pancreatic cancer. Three studies reported the odds ratios (ORs) or relative abundance of several oral microbiomes pieces/clusters, and the majority were associated with pancreatic cancer. Conclusions: Overall, this study supports the hypothesis of associations of variations of patients’ oral microbiota to pancreatic cancer. Nonetheless, due to all included studies were conducted in USA or Europe, additional original studies and meta-analysis particular studies from other countries are essential for an in-depth investigation into the role of oral bacteria in pancreatic cancer.
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