A novel approach for the synthesis of a variety of polysubstituted trans-2,3-dihydropyrroles from a wide range of chalcones and β-enamine ketones (esters) via iodine-promoted tandem Michael/cyclization sequence has been developed, affording the desired products in moderate to excellent yields. This methodology is a highly efficient, convenient way to access functionalized 2,3-dihydropyrroles from readily accessible substrates under mild reaction conditions.
Polysubstituted pyrroles are synthesized from β‐enamines and nitroolefins in the presence of iodine as the catalyst using a high‐speed vibration milling (HSVM) technique under neat conditions.
An efficient protocol was successfully achieved to give 1,3-cyclohexadiene derivatives in good to excellent yields from chalcones and β-enamine ketones (esters) promoted by AlCl3.
Synthesis of Pyrroles from -Enamines and Nitroolefins Catalyzed by I 2 under High-Speed Vibration Milling (HSVM). -Polysubstituted pyrroles are synthesized from -enamines and nitroolefins in the presence of iodine as the catalyst using a high--speed vibration milling (HSVM) technique under neat conditions. The influences of the vibration frequency and the reaction time are investigated and a series of 2,3,4-polysubstituted pyrroles is obtained in good yields within short reaction times (20 min). -(XU, H.; LI, Y.; XING, M.; JIA, J.; HAN, L.; YE, Q.; GAO*, J.; Chem. Lett. 44 (2015) 4, 574-576, http://dx.
Iodine-Promoted Construction of Polysubstituted 2,3-Dihydropyrroles from Chalcones and -Enamine Ketones (Esters). -The convenient synthesis is performed under mild reaction conditions and provides a variety of polysubstituted 2,3-dihydropyrroles in high yields. -(LI, Y.; XU, H.; XING, M.; HUANG, F.; JIA, J.; GAO*, J.; Org. Lett. 17 (2015) 15, 3690-3693, http://dx.doi.org/10.1021/acs.orglett.5b01652 ; Coll. Chem. Eng., Zhejiang Univ. Technol.,
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